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Effects of Metabolites Derived From Gut Microbiota and Hosts on Pathogens

Intestinal metabolites participate in various physiological processes, including energy metabolism, cell-to-cell communication, and host immunity. These metabolites mainly originate from gut microbiota and hosts. Although many host metabolites are dominant in intestines, such as free fatty acids, am...

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Autores principales: Li, Zhendong, Quan, Guomei, Jiang, Xinyi, Yang, Yang, Ding, Xueyan, Zhang, Dong, Wang, Xiuqing, Hardwidge, Philip R., Ren, Wenkai, Zhu, Guoqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152485/
https://www.ncbi.nlm.nih.gov/pubmed/30276161
http://dx.doi.org/10.3389/fcimb.2018.00314
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author Li, Zhendong
Quan, Guomei
Jiang, Xinyi
Yang, Yang
Ding, Xueyan
Zhang, Dong
Wang, Xiuqing
Hardwidge, Philip R.
Ren, Wenkai
Zhu, Guoqiang
author_facet Li, Zhendong
Quan, Guomei
Jiang, Xinyi
Yang, Yang
Ding, Xueyan
Zhang, Dong
Wang, Xiuqing
Hardwidge, Philip R.
Ren, Wenkai
Zhu, Guoqiang
author_sort Li, Zhendong
collection PubMed
description Intestinal metabolites participate in various physiological processes, including energy metabolism, cell-to-cell communication, and host immunity. These metabolites mainly originate from gut microbiota and hosts. Although many host metabolites are dominant in intestines, such as free fatty acids, amino acids and vitamins, the metabolites derived from gut microbiota are also essential for intestinal homeostasis. In addition, some metabolites are only generated and released by gut microbiota, such as bacteriocins, short-chain fatty acids, and quorum-sensing autoinducers. In this review, we summarize recent studies regarding the crosstalk between pathogens and metabolites from different sources, including the influence on bacterial development and the activation/inhibition of immune responses of hosts. All of these functions would affect the colonization of and infection by pathogens. This review provides clear ideas and directions for further exploring the regulatory mechanisms and effects of metabolites on pathogens.
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spelling pubmed-61524852018-10-01 Effects of Metabolites Derived From Gut Microbiota and Hosts on Pathogens Li, Zhendong Quan, Guomei Jiang, Xinyi Yang, Yang Ding, Xueyan Zhang, Dong Wang, Xiuqing Hardwidge, Philip R. Ren, Wenkai Zhu, Guoqiang Front Cell Infect Microbiol Cellular and Infection Microbiology Intestinal metabolites participate in various physiological processes, including energy metabolism, cell-to-cell communication, and host immunity. These metabolites mainly originate from gut microbiota and hosts. Although many host metabolites are dominant in intestines, such as free fatty acids, amino acids and vitamins, the metabolites derived from gut microbiota are also essential for intestinal homeostasis. In addition, some metabolites are only generated and released by gut microbiota, such as bacteriocins, short-chain fatty acids, and quorum-sensing autoinducers. In this review, we summarize recent studies regarding the crosstalk between pathogens and metabolites from different sources, including the influence on bacterial development and the activation/inhibition of immune responses of hosts. All of these functions would affect the colonization of and infection by pathogens. This review provides clear ideas and directions for further exploring the regulatory mechanisms and effects of metabolites on pathogens. Frontiers Media S.A. 2018-09-14 /pmc/articles/PMC6152485/ /pubmed/30276161 http://dx.doi.org/10.3389/fcimb.2018.00314 Text en Copyright © 2018 Li, Quan, Jiang, Yang, Ding, Zhang, Wang, Hardwidge, Ren and Zhu. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cellular and Infection Microbiology
Li, Zhendong
Quan, Guomei
Jiang, Xinyi
Yang, Yang
Ding, Xueyan
Zhang, Dong
Wang, Xiuqing
Hardwidge, Philip R.
Ren, Wenkai
Zhu, Guoqiang
Effects of Metabolites Derived From Gut Microbiota and Hosts on Pathogens
title Effects of Metabolites Derived From Gut Microbiota and Hosts on Pathogens
title_full Effects of Metabolites Derived From Gut Microbiota and Hosts on Pathogens
title_fullStr Effects of Metabolites Derived From Gut Microbiota and Hosts on Pathogens
title_full_unstemmed Effects of Metabolites Derived From Gut Microbiota and Hosts on Pathogens
title_short Effects of Metabolites Derived From Gut Microbiota and Hosts on Pathogens
title_sort effects of metabolites derived from gut microbiota and hosts on pathogens
topic Cellular and Infection Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152485/
https://www.ncbi.nlm.nih.gov/pubmed/30276161
http://dx.doi.org/10.3389/fcimb.2018.00314
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