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Effects of Metabolites Derived From Gut Microbiota and Hosts on Pathogens
Intestinal metabolites participate in various physiological processes, including energy metabolism, cell-to-cell communication, and host immunity. These metabolites mainly originate from gut microbiota and hosts. Although many host metabolites are dominant in intestines, such as free fatty acids, am...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152485/ https://www.ncbi.nlm.nih.gov/pubmed/30276161 http://dx.doi.org/10.3389/fcimb.2018.00314 |
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author | Li, Zhendong Quan, Guomei Jiang, Xinyi Yang, Yang Ding, Xueyan Zhang, Dong Wang, Xiuqing Hardwidge, Philip R. Ren, Wenkai Zhu, Guoqiang |
author_facet | Li, Zhendong Quan, Guomei Jiang, Xinyi Yang, Yang Ding, Xueyan Zhang, Dong Wang, Xiuqing Hardwidge, Philip R. Ren, Wenkai Zhu, Guoqiang |
author_sort | Li, Zhendong |
collection | PubMed |
description | Intestinal metabolites participate in various physiological processes, including energy metabolism, cell-to-cell communication, and host immunity. These metabolites mainly originate from gut microbiota and hosts. Although many host metabolites are dominant in intestines, such as free fatty acids, amino acids and vitamins, the metabolites derived from gut microbiota are also essential for intestinal homeostasis. In addition, some metabolites are only generated and released by gut microbiota, such as bacteriocins, short-chain fatty acids, and quorum-sensing autoinducers. In this review, we summarize recent studies regarding the crosstalk between pathogens and metabolites from different sources, including the influence on bacterial development and the activation/inhibition of immune responses of hosts. All of these functions would affect the colonization of and infection by pathogens. This review provides clear ideas and directions for further exploring the regulatory mechanisms and effects of metabolites on pathogens. |
format | Online Article Text |
id | pubmed-6152485 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-61524852018-10-01 Effects of Metabolites Derived From Gut Microbiota and Hosts on Pathogens Li, Zhendong Quan, Guomei Jiang, Xinyi Yang, Yang Ding, Xueyan Zhang, Dong Wang, Xiuqing Hardwidge, Philip R. Ren, Wenkai Zhu, Guoqiang Front Cell Infect Microbiol Cellular and Infection Microbiology Intestinal metabolites participate in various physiological processes, including energy metabolism, cell-to-cell communication, and host immunity. These metabolites mainly originate from gut microbiota and hosts. Although many host metabolites are dominant in intestines, such as free fatty acids, amino acids and vitamins, the metabolites derived from gut microbiota are also essential for intestinal homeostasis. In addition, some metabolites are only generated and released by gut microbiota, such as bacteriocins, short-chain fatty acids, and quorum-sensing autoinducers. In this review, we summarize recent studies regarding the crosstalk between pathogens and metabolites from different sources, including the influence on bacterial development and the activation/inhibition of immune responses of hosts. All of these functions would affect the colonization of and infection by pathogens. This review provides clear ideas and directions for further exploring the regulatory mechanisms and effects of metabolites on pathogens. Frontiers Media S.A. 2018-09-14 /pmc/articles/PMC6152485/ /pubmed/30276161 http://dx.doi.org/10.3389/fcimb.2018.00314 Text en Copyright © 2018 Li, Quan, Jiang, Yang, Ding, Zhang, Wang, Hardwidge, Ren and Zhu. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cellular and Infection Microbiology Li, Zhendong Quan, Guomei Jiang, Xinyi Yang, Yang Ding, Xueyan Zhang, Dong Wang, Xiuqing Hardwidge, Philip R. Ren, Wenkai Zhu, Guoqiang Effects of Metabolites Derived From Gut Microbiota and Hosts on Pathogens |
title | Effects of Metabolites Derived From Gut Microbiota and Hosts on Pathogens |
title_full | Effects of Metabolites Derived From Gut Microbiota and Hosts on Pathogens |
title_fullStr | Effects of Metabolites Derived From Gut Microbiota and Hosts on Pathogens |
title_full_unstemmed | Effects of Metabolites Derived From Gut Microbiota and Hosts on Pathogens |
title_short | Effects of Metabolites Derived From Gut Microbiota and Hosts on Pathogens |
title_sort | effects of metabolites derived from gut microbiota and hosts on pathogens |
topic | Cellular and Infection Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152485/ https://www.ncbi.nlm.nih.gov/pubmed/30276161 http://dx.doi.org/10.3389/fcimb.2018.00314 |
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