14,15-Secopregnane-Type Glycosides with 5α:9α-Peroxy and Δ(6,8(14))-diene Linkages from the Roots of Cynanchum stauntonii

Three new 14,15-secopregnane-type glycosides, stauntosides UA, UA(1), and UA(2), were isolated from the roots of Cynanchum stauntonii. The three compounds share the first reported and same basic structural features of 3β-hydroxy-14:16,15:20,18:20-triepoxy-5α:9α-peroxy-14,15-secopregnane-6,8(14)-dien...

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Detalles Bibliográficos
Autores principales: Deng, An-Jun, Yu, Jin-Qian, Li, Zhi-Hong, Ma, Lin, Zhang, Zhi-Hui, Qin, Hai-Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152625/
https://www.ncbi.nlm.nih.gov/pubmed/28545240
http://dx.doi.org/10.3390/molecules22060860
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author Deng, An-Jun
Yu, Jin-Qian
Li, Zhi-Hong
Ma, Lin
Zhang, Zhi-Hui
Qin, Hai-Lin
author_facet Deng, An-Jun
Yu, Jin-Qian
Li, Zhi-Hong
Ma, Lin
Zhang, Zhi-Hui
Qin, Hai-Lin
author_sort Deng, An-Jun
collection PubMed
description Three new 14,15-secopregnane-type glycosides, stauntosides UA, UA(1), and UA(2), were isolated from the roots of Cynanchum stauntonii. The three compounds share the first reported and same basic structural features of 3β-hydroxy-14:16,15:20,18:20-triepoxy-5α:9α-peroxy-14,15-secopregnane-6,8(14)-diene named as stauntogenin G as the aglycones. The structures of the new compounds were characterized on the basis of extensive spectroscopic analyses, mainly 1D and 2D NMR and MS methods and chemical analysis. The isolation and identification of the new compounds graced the structural diversity of pregnane-type steroids from C. stauntonii.
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spelling pubmed-61526252018-11-13 14,15-Secopregnane-Type Glycosides with 5α:9α-Peroxy and Δ(6,8(14))-diene Linkages from the Roots of Cynanchum stauntonii Deng, An-Jun Yu, Jin-Qian Li, Zhi-Hong Ma, Lin Zhang, Zhi-Hui Qin, Hai-Lin Molecules Article Three new 14,15-secopregnane-type glycosides, stauntosides UA, UA(1), and UA(2), were isolated from the roots of Cynanchum stauntonii. The three compounds share the first reported and same basic structural features of 3β-hydroxy-14:16,15:20,18:20-triepoxy-5α:9α-peroxy-14,15-secopregnane-6,8(14)-diene named as stauntogenin G as the aglycones. The structures of the new compounds were characterized on the basis of extensive spectroscopic analyses, mainly 1D and 2D NMR and MS methods and chemical analysis. The isolation and identification of the new compounds graced the structural diversity of pregnane-type steroids from C. stauntonii. MDPI 2017-05-23 /pmc/articles/PMC6152625/ /pubmed/28545240 http://dx.doi.org/10.3390/molecules22060860 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Deng, An-Jun
Yu, Jin-Qian
Li, Zhi-Hong
Ma, Lin
Zhang, Zhi-Hui
Qin, Hai-Lin
14,15-Secopregnane-Type Glycosides with 5α:9α-Peroxy and Δ(6,8(14))-diene Linkages from the Roots of Cynanchum stauntonii
title 14,15-Secopregnane-Type Glycosides with 5α:9α-Peroxy and Δ(6,8(14))-diene Linkages from the Roots of Cynanchum stauntonii
title_full 14,15-Secopregnane-Type Glycosides with 5α:9α-Peroxy and Δ(6,8(14))-diene Linkages from the Roots of Cynanchum stauntonii
title_fullStr 14,15-Secopregnane-Type Glycosides with 5α:9α-Peroxy and Δ(6,8(14))-diene Linkages from the Roots of Cynanchum stauntonii
title_full_unstemmed 14,15-Secopregnane-Type Glycosides with 5α:9α-Peroxy and Δ(6,8(14))-diene Linkages from the Roots of Cynanchum stauntonii
title_short 14,15-Secopregnane-Type Glycosides with 5α:9α-Peroxy and Δ(6,8(14))-diene Linkages from the Roots of Cynanchum stauntonii
title_sort 14,15-secopregnane-type glycosides with 5α:9α-peroxy and δ(6,8(14))-diene linkages from the roots of cynanchum stauntonii
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152625/
https://www.ncbi.nlm.nih.gov/pubmed/28545240
http://dx.doi.org/10.3390/molecules22060860
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