Phenolic Glycosides from Capsella bursa-pastoris (L.) Medik and Their Anti-Inflammatory Activity

A new sesquilignan glycoside 1, together with seven known phenolic glycosides 2–8 were isolated from the aerial parts of Capsella bursa-pastoris. The chemical structure of the new compound 1 was elucidated by extensive nuclear magnetic resonance (NMR) data ((1)H- and (13)C-NMR, (1)H-(1)H correlation...

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Detalles Bibliográficos
Autores principales: Cha, Joon Min, Suh, Won Se, Lee, Tae Hyun, Subedi, Lalita, Kim, Sun Yeou, Lee, Kang Ro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152647/
https://www.ncbi.nlm.nih.gov/pubmed/28632189
http://dx.doi.org/10.3390/molecules22061023
Descripción
Sumario:A new sesquilignan glycoside 1, together with seven known phenolic glycosides 2–8 were isolated from the aerial parts of Capsella bursa-pastoris. The chemical structure of the new compound 1 was elucidated by extensive nuclear magnetic resonance (NMR) data ((1)H- and (13)C-NMR, (1)H-(1)H correlation spectroscopy ((1)H-(1)H COSY), heteronuclear single-quantum correlation (HSQC), heteronuclear multiple bond correlation (HMBC), and nuclear overhauser effect spectroscopy (NOESY)) and HR-FABMS analysis. The anti-inflammatory effects of 1–8 were evaluated in lipopolysaccharide (LPS)-stimulated murine microglia BV-2 cells. Compounds 4 and 7 exhibited moderate inhibitory effects on nitric oxide production in LPS-activated BV-2 cells, with IC(50) values of 17.80 and 27.91 µM, respectively.

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