Cancer Chemoprevention by Resveratrol: The p53 Tumor Suppressor Protein as a Promising Molecular Target

Increasing epidemiological and experimental evidence has demonstrated an inverse relationship between the consumption of plant foods and the incidence of chronic diseases, including cancer. Microcomponents that are naturally present in such foods, especially polyphenols, are responsible for the bene...

Descripción completa

Detalles Bibliográficos
Autores principales: Ferraz da Costa, Danielly C., Fialho, Eliane, Silva, Jerson L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152653/
https://www.ncbi.nlm.nih.gov/pubmed/28629161
http://dx.doi.org/10.3390/molecules22061014
_version_ 1783357404544499712
author Ferraz da Costa, Danielly C.
Fialho, Eliane
Silva, Jerson L.
author_facet Ferraz da Costa, Danielly C.
Fialho, Eliane
Silva, Jerson L.
author_sort Ferraz da Costa, Danielly C.
collection PubMed
description Increasing epidemiological and experimental evidence has demonstrated an inverse relationship between the consumption of plant foods and the incidence of chronic diseases, including cancer. Microcomponents that are naturally present in such foods, especially polyphenols, are responsible for the benefits to human health. Resveratrol is a diet-derived cancer chemopreventive agent with high therapeutic potential, as demonstrated by different authors. The aim of this review is to collect and present recent evidence from the literature regarding resveratrol and its effects on cancer prevention, molecular signaling (especially regarding the involvement of p53 protein), and therapeutic perspectives with an emphasis on clinical trial results to date.
format Online
Article
Text
id pubmed-6152653
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-61526532018-11-13 Cancer Chemoprevention by Resveratrol: The p53 Tumor Suppressor Protein as a Promising Molecular Target Ferraz da Costa, Danielly C. Fialho, Eliane Silva, Jerson L. Molecules Review Increasing epidemiological and experimental evidence has demonstrated an inverse relationship between the consumption of plant foods and the incidence of chronic diseases, including cancer. Microcomponents that are naturally present in such foods, especially polyphenols, are responsible for the benefits to human health. Resveratrol is a diet-derived cancer chemopreventive agent with high therapeutic potential, as demonstrated by different authors. The aim of this review is to collect and present recent evidence from the literature regarding resveratrol and its effects on cancer prevention, molecular signaling (especially regarding the involvement of p53 protein), and therapeutic perspectives with an emphasis on clinical trial results to date. MDPI 2017-06-18 /pmc/articles/PMC6152653/ /pubmed/28629161 http://dx.doi.org/10.3390/molecules22061014 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ferraz da Costa, Danielly C.
Fialho, Eliane
Silva, Jerson L.
Cancer Chemoprevention by Resveratrol: The p53 Tumor Suppressor Protein as a Promising Molecular Target
title Cancer Chemoprevention by Resveratrol: The p53 Tumor Suppressor Protein as a Promising Molecular Target
title_full Cancer Chemoprevention by Resveratrol: The p53 Tumor Suppressor Protein as a Promising Molecular Target
title_fullStr Cancer Chemoprevention by Resveratrol: The p53 Tumor Suppressor Protein as a Promising Molecular Target
title_full_unstemmed Cancer Chemoprevention by Resveratrol: The p53 Tumor Suppressor Protein as a Promising Molecular Target
title_short Cancer Chemoprevention by Resveratrol: The p53 Tumor Suppressor Protein as a Promising Molecular Target
title_sort cancer chemoprevention by resveratrol: the p53 tumor suppressor protein as a promising molecular target
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152653/
https://www.ncbi.nlm.nih.gov/pubmed/28629161
http://dx.doi.org/10.3390/molecules22061014
work_keys_str_mv AT ferrazdacostadaniellyc cancerchemopreventionbyresveratrolthep53tumorsuppressorproteinasapromisingmoleculartarget
AT fialhoeliane cancerchemopreventionbyresveratrolthep53tumorsuppressorproteinasapromisingmoleculartarget
AT silvajersonl cancerchemopreventionbyresveratrolthep53tumorsuppressorproteinasapromisingmoleculartarget

Ejemplares similares