Protein Interaction and Na/K-ATPase-Mediated Signal Transduction

The Na/K-ATPase (NKA), or Na pump, is a member of the P-type ATPase superfamily. In addition to pumping ions across cell membrane, it is engaged in assembly of multiple protein complexes in the plasma membrane. This assembly allows NKA to perform many non-pumping functions including signal transduct...

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Detalles Bibliográficos
Autores principales: Cui, Xiaoyu, Xie, Zijian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152704/
https://www.ncbi.nlm.nih.gov/pubmed/28613263
http://dx.doi.org/10.3390/molecules22060990
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author Cui, Xiaoyu
Xie, Zijian
author_facet Cui, Xiaoyu
Xie, Zijian
author_sort Cui, Xiaoyu
collection PubMed
description The Na/K-ATPase (NKA), or Na pump, is a member of the P-type ATPase superfamily. In addition to pumping ions across cell membrane, it is engaged in assembly of multiple protein complexes in the plasma membrane. This assembly allows NKA to perform many non-pumping functions including signal transduction that are important for animal physiology and disease progression. This article will focus on the role of protein interaction in NKA-mediated signal transduction, and its potential utility as target for developing new therapeutics.
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spelling pubmed-61527042018-11-13 Protein Interaction and Na/K-ATPase-Mediated Signal Transduction Cui, Xiaoyu Xie, Zijian Molecules Review The Na/K-ATPase (NKA), or Na pump, is a member of the P-type ATPase superfamily. In addition to pumping ions across cell membrane, it is engaged in assembly of multiple protein complexes in the plasma membrane. This assembly allows NKA to perform many non-pumping functions including signal transduction that are important for animal physiology and disease progression. This article will focus on the role of protein interaction in NKA-mediated signal transduction, and its potential utility as target for developing new therapeutics. MDPI 2017-06-14 /pmc/articles/PMC6152704/ /pubmed/28613263 http://dx.doi.org/10.3390/molecules22060990 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Cui, Xiaoyu
Xie, Zijian
Protein Interaction and Na/K-ATPase-Mediated Signal Transduction
title Protein Interaction and Na/K-ATPase-Mediated Signal Transduction
title_full Protein Interaction and Na/K-ATPase-Mediated Signal Transduction
title_fullStr Protein Interaction and Na/K-ATPase-Mediated Signal Transduction
title_full_unstemmed Protein Interaction and Na/K-ATPase-Mediated Signal Transduction
title_short Protein Interaction and Na/K-ATPase-Mediated Signal Transduction
title_sort protein interaction and na/k-atpase-mediated signal transduction
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152704/
https://www.ncbi.nlm.nih.gov/pubmed/28613263
http://dx.doi.org/10.3390/molecules22060990
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AT xiezijian proteininteractionandnakatpasemediatedsignaltransduction

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