New Benzenoid Derivatives and Other Constituents from Lawsonia inermis with Inhibitory Activity against NO Production

Three new benzenoid derivatives, lawsoinermone (1), inermidioic acid (2), and inermic acid (3) have been isolated from the aerial part of Lawsonia inermis, together with 11 known compounds (4–14). The structures of three new compounds were determined through spectroscopic and MS analyses. Compounds...

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Detalles Bibliográficos
Autores principales: Yang, Chang-Syun, Chen, Jih-Jung, Huang, Hui-Chi, Huang, Guan-Jhong, Wang, Sheng-Yang, Sung, Ping-Jyun, Cheng, Ming-Jen, Wu, Ming-Der, Kuo, Yueh-Hsiung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152715/
https://www.ncbi.nlm.nih.gov/pubmed/28587259
http://dx.doi.org/10.3390/molecules22060936
Descripción
Sumario:Three new benzenoid derivatives, lawsoinermone (1), inermidioic acid (2), and inermic acid (3) have been isolated from the aerial part of Lawsonia inermis, together with 11 known compounds (4–14). The structures of three new compounds were determined through spectroscopic and MS analyses. Compounds 1, 4–6, 13 and 14 were evaluated for inhibition of nitric oxide production in LPS-stimulated product of nitrite in RAW 264.7 cells with IC(50) values of 6.12, 16.43, 18.98, 9.30, 9.30 and 14.90 μg/mL, respectively.

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