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New Benzenoid Derivatives and Other Constituents from Lawsonia inermis with Inhibitory Activity against NO Production
Three new benzenoid derivatives, lawsoinermone (1), inermidioic acid (2), and inermic acid (3) have been isolated from the aerial part of Lawsonia inermis, together with 11 known compounds (4–14). The structures of three new compounds were determined through spectroscopic and MS analyses. Compounds...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152715/ https://www.ncbi.nlm.nih.gov/pubmed/28587259 http://dx.doi.org/10.3390/molecules22060936 |
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| author | Yang, Chang-Syun Chen, Jih-Jung Huang, Hui-Chi Huang, Guan-Jhong Wang, Sheng-Yang Sung, Ping-Jyun Cheng, Ming-Jen Wu, Ming-Der Kuo, Yueh-Hsiung |
| author_facet | Yang, Chang-Syun Chen, Jih-Jung Huang, Hui-Chi Huang, Guan-Jhong Wang, Sheng-Yang Sung, Ping-Jyun Cheng, Ming-Jen Wu, Ming-Der Kuo, Yueh-Hsiung |
| author_sort | Yang, Chang-Syun |
| collection | PubMed |
| description | Three new benzenoid derivatives, lawsoinermone (1), inermidioic acid (2), and inermic acid (3) have been isolated from the aerial part of Lawsonia inermis, together with 11 known compounds (4–14). The structures of three new compounds were determined through spectroscopic and MS analyses. Compounds 1, 4–6, 13 and 14 were evaluated for inhibition of nitric oxide production in LPS-stimulated product of nitrite in RAW 264.7 cells with IC(50) values of 6.12, 16.43, 18.98, 9.30, 9.30 and 14.90 μg/mL, respectively. |
| format | Online Article Text |
| id | pubmed-6152715 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2017 |
| publisher | MDPI |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-61527152018-11-13 New Benzenoid Derivatives and Other Constituents from Lawsonia inermis with Inhibitory Activity against NO Production Yang, Chang-Syun Chen, Jih-Jung Huang, Hui-Chi Huang, Guan-Jhong Wang, Sheng-Yang Sung, Ping-Jyun Cheng, Ming-Jen Wu, Ming-Der Kuo, Yueh-Hsiung Molecules Article Three new benzenoid derivatives, lawsoinermone (1), inermidioic acid (2), and inermic acid (3) have been isolated from the aerial part of Lawsonia inermis, together with 11 known compounds (4–14). The structures of three new compounds were determined through spectroscopic and MS analyses. Compounds 1, 4–6, 13 and 14 were evaluated for inhibition of nitric oxide production in LPS-stimulated product of nitrite in RAW 264.7 cells with IC(50) values of 6.12, 16.43, 18.98, 9.30, 9.30 and 14.90 μg/mL, respectively. MDPI 2017-06-05 /pmc/articles/PMC6152715/ /pubmed/28587259 http://dx.doi.org/10.3390/molecules22060936 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
| spellingShingle | Article Yang, Chang-Syun Chen, Jih-Jung Huang, Hui-Chi Huang, Guan-Jhong Wang, Sheng-Yang Sung, Ping-Jyun Cheng, Ming-Jen Wu, Ming-Der Kuo, Yueh-Hsiung New Benzenoid Derivatives and Other Constituents from Lawsonia inermis with Inhibitory Activity against NO Production |
| title | New Benzenoid Derivatives and Other Constituents from Lawsonia inermis with Inhibitory Activity against NO Production |
| title_full | New Benzenoid Derivatives and Other Constituents from Lawsonia inermis with Inhibitory Activity against NO Production |
| title_fullStr | New Benzenoid Derivatives and Other Constituents from Lawsonia inermis with Inhibitory Activity against NO Production |
| title_full_unstemmed | New Benzenoid Derivatives and Other Constituents from Lawsonia inermis with Inhibitory Activity against NO Production |
| title_short | New Benzenoid Derivatives and Other Constituents from Lawsonia inermis with Inhibitory Activity against NO Production |
| title_sort | new benzenoid derivatives and other constituents from lawsonia inermis with inhibitory activity against no production |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152715/ https://www.ncbi.nlm.nih.gov/pubmed/28587259 http://dx.doi.org/10.3390/molecules22060936 |
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