Laurus nobilis: Composition of Essential Oil and Its Biological Activities

Laurus nobilis is native to the southern Mediterranean region and cultivated mainly in Europe and the USA as an ornamental and medicinal plant. The chemical composition of the essential oil (EO) from leaves of L. nobilis, collected in Southern Italy, was studied by GC and GC-MS. In all, 55 compounds...

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Autores principales: Caputo, Lucia, Nazzaro, Filomena, Souza, Lucéia Fatima, Aliberti, Luigi, De Martino, Laura, Fratianni, Florinda, Coppola, Raffaele, De Feo, Vincenzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152719/
https://www.ncbi.nlm.nih.gov/pubmed/28587201
http://dx.doi.org/10.3390/molecules22060930
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author Caputo, Lucia
Nazzaro, Filomena
Souza, Lucéia Fatima
Aliberti, Luigi
De Martino, Laura
Fratianni, Florinda
Coppola, Raffaele
De Feo, Vincenzo
author_facet Caputo, Lucia
Nazzaro, Filomena
Souza, Lucéia Fatima
Aliberti, Luigi
De Martino, Laura
Fratianni, Florinda
Coppola, Raffaele
De Feo, Vincenzo
author_sort Caputo, Lucia
collection PubMed
description Laurus nobilis is native to the southern Mediterranean region and cultivated mainly in Europe and the USA as an ornamental and medicinal plant. The chemical composition of the essential oil (EO) from leaves of L. nobilis, collected in Southern Italy, was studied by GC and GC-MS. In all, 55 compounds were identified, accounting for 91.6% of the total essential oil. 1,8-Cineole (31.9%), sabinene (12.2%), and linalool (10.2%) were the main components. Antimicrobial and antifungal activities of EO and 1,8-cineole were determined in vitro. The cytotoxicity of the EO was evaluated against SH-SY5Y cell line, as well as the influence of the EO on the expression of adenylate cyclase 1 (ADCY1), suggesting possible essential oil effects on the Central Nervous System.
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spelling pubmed-61527192018-11-13 Laurus nobilis: Composition of Essential Oil and Its Biological Activities Caputo, Lucia Nazzaro, Filomena Souza, Lucéia Fatima Aliberti, Luigi De Martino, Laura Fratianni, Florinda Coppola, Raffaele De Feo, Vincenzo Molecules Article Laurus nobilis is native to the southern Mediterranean region and cultivated mainly in Europe and the USA as an ornamental and medicinal plant. The chemical composition of the essential oil (EO) from leaves of L. nobilis, collected in Southern Italy, was studied by GC and GC-MS. In all, 55 compounds were identified, accounting for 91.6% of the total essential oil. 1,8-Cineole (31.9%), sabinene (12.2%), and linalool (10.2%) were the main components. Antimicrobial and antifungal activities of EO and 1,8-cineole were determined in vitro. The cytotoxicity of the EO was evaluated against SH-SY5Y cell line, as well as the influence of the EO on the expression of adenylate cyclase 1 (ADCY1), suggesting possible essential oil effects on the Central Nervous System. MDPI 2017-06-03 /pmc/articles/PMC6152719/ /pubmed/28587201 http://dx.doi.org/10.3390/molecules22060930 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Caputo, Lucia
Nazzaro, Filomena
Souza, Lucéia Fatima
Aliberti, Luigi
De Martino, Laura
Fratianni, Florinda
Coppola, Raffaele
De Feo, Vincenzo
Laurus nobilis: Composition of Essential Oil and Its Biological Activities
title Laurus nobilis: Composition of Essential Oil and Its Biological Activities
title_full Laurus nobilis: Composition of Essential Oil and Its Biological Activities
title_fullStr Laurus nobilis: Composition of Essential Oil and Its Biological Activities
title_full_unstemmed Laurus nobilis: Composition of Essential Oil and Its Biological Activities
title_short Laurus nobilis: Composition of Essential Oil and Its Biological Activities
title_sort laurus nobilis: composition of essential oil and its biological activities
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152719/
https://www.ncbi.nlm.nih.gov/pubmed/28587201
http://dx.doi.org/10.3390/molecules22060930
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