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Dynamic Allostery Modulates Catalytic Activity by Modifying the Hydrogen Bonding Network in the Catalytic Site of Human Pin1

Allosteric communication among domains in modular proteins consisting of flexibly linked domains with complimentary roles remains poorly understood. To understand how complementary domains communicate, we have studied human Pin1, a representative modular protein with two domains mutually tethered by...

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Detalles Bibliográficos
Autores principales:	Wang, Jing, Kawasaki, Ryosuke, Uewaki, Jun-ichi, Rashid, Arif U. R., Tochio, Naoya, Tate, Shin-ichi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152768/ https://www.ncbi.nlm.nih.gov/pubmed/28617332 http://dx.doi.org/10.3390/molecules22060992

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