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Chemical Methods to Knock Down the Amyloid Proteins

Amyloid proteins are closely related with amyloid diseases and do tremendous harm to human health. However, there is still a lack of effective strategies to treat these amyloid diseases, so it is important to develop novel methods. Accelerating the clearance of amyloid proteins is a favorable method...

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Detalles Bibliográficos
Autores principales: Gao, Na, Chen, Yong-Xiang, Zhao, Yu-Fen, Li, Yan-Mei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152772/
https://www.ncbi.nlm.nih.gov/pubmed/28587164
http://dx.doi.org/10.3390/molecules22060916
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author Gao, Na
Chen, Yong-Xiang
Zhao, Yu-Fen
Li, Yan-Mei
author_facet Gao, Na
Chen, Yong-Xiang
Zhao, Yu-Fen
Li, Yan-Mei
author_sort Gao, Na
collection PubMed
description Amyloid proteins are closely related with amyloid diseases and do tremendous harm to human health. However, there is still a lack of effective strategies to treat these amyloid diseases, so it is important to develop novel methods. Accelerating the clearance of amyloid proteins is a favorable method for amyloid disease treatment. Recently, chemical methods for protein reduction have been developed and have attracted much attention. In this review, we focus on the latest progress of chemical methods that knock down amyloid proteins, including the proteolysis-targeting chimera (PROTAC) strategy, the “recognition-cleavage” strategy, the chaperone-mediated autophagy (CMA) strategy, the selectively light-activatable organic and inorganic molecules strategy and other chemical strategies.
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spelling pubmed-61527722018-11-13 Chemical Methods to Knock Down the Amyloid Proteins Gao, Na Chen, Yong-Xiang Zhao, Yu-Fen Li, Yan-Mei Molecules Review Amyloid proteins are closely related with amyloid diseases and do tremendous harm to human health. However, there is still a lack of effective strategies to treat these amyloid diseases, so it is important to develop novel methods. Accelerating the clearance of amyloid proteins is a favorable method for amyloid disease treatment. Recently, chemical methods for protein reduction have been developed and have attracted much attention. In this review, we focus on the latest progress of chemical methods that knock down amyloid proteins, including the proteolysis-targeting chimera (PROTAC) strategy, the “recognition-cleavage” strategy, the chaperone-mediated autophagy (CMA) strategy, the selectively light-activatable organic and inorganic molecules strategy and other chemical strategies. MDPI 2017-06-01 /pmc/articles/PMC6152772/ /pubmed/28587164 http://dx.doi.org/10.3390/molecules22060916 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Gao, Na
Chen, Yong-Xiang
Zhao, Yu-Fen
Li, Yan-Mei
Chemical Methods to Knock Down the Amyloid Proteins
title Chemical Methods to Knock Down the Amyloid Proteins
title_full Chemical Methods to Knock Down the Amyloid Proteins
title_fullStr Chemical Methods to Knock Down the Amyloid Proteins
title_full_unstemmed Chemical Methods to Knock Down the Amyloid Proteins
title_short Chemical Methods to Knock Down the Amyloid Proteins
title_sort chemical methods to knock down the amyloid proteins
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152772/
https://www.ncbi.nlm.nih.gov/pubmed/28587164
http://dx.doi.org/10.3390/molecules22060916
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