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Chemical Methods to Knock Down the Amyloid Proteins
Amyloid proteins are closely related with amyloid diseases and do tremendous harm to human health. However, there is still a lack of effective strategies to treat these amyloid diseases, so it is important to develop novel methods. Accelerating the clearance of amyloid proteins is a favorable method...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152772/ https://www.ncbi.nlm.nih.gov/pubmed/28587164 http://dx.doi.org/10.3390/molecules22060916 |
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author | Gao, Na Chen, Yong-Xiang Zhao, Yu-Fen Li, Yan-Mei |
author_facet | Gao, Na Chen, Yong-Xiang Zhao, Yu-Fen Li, Yan-Mei |
author_sort | Gao, Na |
collection | PubMed |
description | Amyloid proteins are closely related with amyloid diseases and do tremendous harm to human health. However, there is still a lack of effective strategies to treat these amyloid diseases, so it is important to develop novel methods. Accelerating the clearance of amyloid proteins is a favorable method for amyloid disease treatment. Recently, chemical methods for protein reduction have been developed and have attracted much attention. In this review, we focus on the latest progress of chemical methods that knock down amyloid proteins, including the proteolysis-targeting chimera (PROTAC) strategy, the “recognition-cleavage” strategy, the chaperone-mediated autophagy (CMA) strategy, the selectively light-activatable organic and inorganic molecules strategy and other chemical strategies. |
format | Online Article Text |
id | pubmed-6152772 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-61527722018-11-13 Chemical Methods to Knock Down the Amyloid Proteins Gao, Na Chen, Yong-Xiang Zhao, Yu-Fen Li, Yan-Mei Molecules Review Amyloid proteins are closely related with amyloid diseases and do tremendous harm to human health. However, there is still a lack of effective strategies to treat these amyloid diseases, so it is important to develop novel methods. Accelerating the clearance of amyloid proteins is a favorable method for amyloid disease treatment. Recently, chemical methods for protein reduction have been developed and have attracted much attention. In this review, we focus on the latest progress of chemical methods that knock down amyloid proteins, including the proteolysis-targeting chimera (PROTAC) strategy, the “recognition-cleavage” strategy, the chaperone-mediated autophagy (CMA) strategy, the selectively light-activatable organic and inorganic molecules strategy and other chemical strategies. MDPI 2017-06-01 /pmc/articles/PMC6152772/ /pubmed/28587164 http://dx.doi.org/10.3390/molecules22060916 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Gao, Na Chen, Yong-Xiang Zhao, Yu-Fen Li, Yan-Mei Chemical Methods to Knock Down the Amyloid Proteins |
title | Chemical Methods to Knock Down the Amyloid Proteins |
title_full | Chemical Methods to Knock Down the Amyloid Proteins |
title_fullStr | Chemical Methods to Knock Down the Amyloid Proteins |
title_full_unstemmed | Chemical Methods to Knock Down the Amyloid Proteins |
title_short | Chemical Methods to Knock Down the Amyloid Proteins |
title_sort | chemical methods to knock down the amyloid proteins |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152772/ https://www.ncbi.nlm.nih.gov/pubmed/28587164 http://dx.doi.org/10.3390/molecules22060916 |
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