Phloroglucinols with Antioxidant Activities Isolated from Lysidice rhodostegia

Two new phloroglucinols, lysidisides X and Y (1 and 2), and two known compounds, 2-(2-methylbutyryl)phloroglucinol 1-O-β-d-glucopyranoside (3) and (E)-resveratrol 3-(6″-galloyl)-O-β-d-glucopyranoside (4), have been isolated from the roots of Lysidice rhodostegia. The structures of 1 and 2 were eluci...

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Detalles Bibliográficos
Autores principales: Wu, Xian-Fu, Li, Li, Li, Yong, Lv, Hai-Ning, Liu, Yun-Bao, Hu, You-Cai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152794/
https://www.ncbi.nlm.nih.gov/pubmed/28545244
http://dx.doi.org/10.3390/molecules22060855
Descripción
Sumario:Two new phloroglucinols, lysidisides X and Y (1 and 2), and two known compounds, 2-(2-methylbutyryl)phloroglucinol 1-O-β-d-glucopyranoside (3) and (E)-resveratrol 3-(6″-galloyl)-O-β-d-glucopyranoside (4), have been isolated from the roots of Lysidice rhodostegia. The structures of 1 and 2 were elucidated primarily by NMR experiments. Their absolute configurations were deduced via circular dichroism (CD) data and electronic circular dichroism (ECD) calculations. Compounds 1 and 2 exhibited significant antioxidative activities with IC(50) values of 12.0 and 11.8 µM, respectively.

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