Glutathione de novo synthesis but not recycling process coordinates with glutamine catabolism to control redox homeostasis and directs murine T cell differentiation

Upon antigen stimulation, T lymphocytes undergo dramatic changes in metabolism to fulfill the bioenergetic, biosynthetic and redox demands of proliferation and differentiation. Glutathione (GSH) plays an essential role in controlling redox balance and cell fate. While GSH can be recycled from Glutat...

Descripción completa

Detalles Bibliográficos
Autores principales: Lian, Gaojian, Gnanaprakasam, JN Rashida, Wang, Tingting, Wu, Ruohan, Chen, Xuyong, Liu, Lingling, Shen, Yuqing, Yang, Mao, Yang, Jun, Chen, Ying, Vasiliou, Vasilis, Cassel, Teresa A, Green, Douglas R, Liu, Yusen, Fan, Teresa WM, Wang, Ruoning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Immunology and Inflammation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152796/
https://www.ncbi.nlm.nih.gov/pubmed/30198844
http://dx.doi.org/10.7554/eLife.36158

Ejemplares similares

Ejemplares similares