One Group's Historical Reflections on DNA Vaccine Development

DNA vaccines were pioneered by several groups in the early 1990s. This article presents the reflections of one of these groups on their work with retroviral vectors in chickens that contributed to the discovery and early development of DNA vaccines. Although the findings were initially met with skep...

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Detalles Bibliográficos
Autores principales: Fynan, Ellen F., Lu, Shan, Robinson, Harriet L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mary Ann Liebert, Inc., publishers 2018
Materias:
Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152846/
https://www.ncbi.nlm.nih.gov/pubmed/30129778
http://dx.doi.org/10.1089/hum.2018.066
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author Fynan, Ellen F.
Lu, Shan
Robinson, Harriet L.
author_facet Fynan, Ellen F.
Lu, Shan
Robinson, Harriet L.
author_sort Fynan, Ellen F.
collection PubMed
description DNA vaccines were pioneered by several groups in the early 1990s. This article presents the reflections of one of these groups on their work with retroviral vectors in chickens that contributed to the discovery and early development of DNA vaccines. Although the findings were initially met with skepticism, the work presented here combined with that of others founded a new method of vaccination: the direct inoculation of purified DNA encoding the target antigen.
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spelling pubmed-61528462018-09-25 One Group's Historical Reflections on DNA Vaccine Development Fynan, Ellen F. Lu, Shan Robinson, Harriet L. Hum Gene Ther Perspective DNA vaccines were pioneered by several groups in the early 1990s. This article presents the reflections of one of these groups on their work with retroviral vectors in chickens that contributed to the discovery and early development of DNA vaccines. Although the findings were initially met with skepticism, the work presented here combined with that of others founded a new method of vaccination: the direct inoculation of purified DNA encoding the target antigen. Mary Ann Liebert, Inc., publishers 2018-09-01 2018-09-17 /pmc/articles/PMC6152846/ /pubmed/30129778 http://dx.doi.org/10.1089/hum.2018.066 Text en © Ellen F. Fynan et al. 2018; Published by Mary Ann Liebert, Inc. This Open Access article is distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Perspective
Fynan, Ellen F.
Lu, Shan
Robinson, Harriet L.
One Group's Historical Reflections on DNA Vaccine Development
title One Group's Historical Reflections on DNA Vaccine Development
title_full One Group's Historical Reflections on DNA Vaccine Development
title_fullStr One Group's Historical Reflections on DNA Vaccine Development
title_full_unstemmed One Group's Historical Reflections on DNA Vaccine Development
title_short One Group's Historical Reflections on DNA Vaccine Development
title_sort one group's historical reflections on dna vaccine development
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152846/
https://www.ncbi.nlm.nih.gov/pubmed/30129778
http://dx.doi.org/10.1089/hum.2018.066
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