The evolutionary landscape of colorectal tumorigenesis

The evolutionary events that cause colorectal adenomas (benign) to progress to carcinomas (malignant) remain largely undetermined. Using multi-region genome/exome sequencing of 24 benign and malignant colorectal tumours, we probe the evolutionary fitness landscape occupied by these neoplasms. Unlike...

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Detalles Bibliográficos
Autores principales: Cross, William, Kovac, Michal, Mustonen, Ville, Temko, Daniel, Davis, Hayley, Baker, Ann-Marie, Biswas, Sujata, Arnold, Roland, Chegwidden, Laura, Gatenbee, Chandler, Anderson, Alexander R, Koelzer, Viktor H, Martinez, Pierre, Jiang, Xiaowei, Domingo, Enric, Woodcock, Dan, Feng, Yun, Kovacova, Monika, Maughan, Tim, Jansen, Marnix, Rodriguez-Justo, Manuel, Ashraf, Shazad, Guy, Richard, Cunningham, Christopher, East, James E, Wedge, David C, Wang, Lai Mun, Palles, Claire, Heinimann, Karl, Sottoriva, Andrea, Leedham, Simon J, Graham, Trevor A, Tomlinson, Ian PM
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152905/
https://www.ncbi.nlm.nih.gov/pubmed/30177804
http://dx.doi.org/10.1038/s41559-018-0642-z

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