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Expression of a recombinant, 4'-Phosphopantetheinylated, active M. tuberculosis fatty acid synthase I in E. coli

BACKGROUND: Fatty acid synthase 1 (FAS I) from Mycobacterium tuberculosis (Mtb) is an essential protein and a promising drug target. FAS I is a multi-functional, multi-domain protein that is organized as a large (1.9 MDa) homohexameric complex. Acyl intermediates produced during fatty acid elongatio...

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Detalles Bibliográficos
Autores principales:	Baron, Szilvia, Peleg, Yoav, Grunwald, Jacob, Morgenstern, David, Elad, Nadav, Peretz, Moshe, Albeck, Shira, Levin, Yishai, Welch, John T., DeWeerd, Kim A., Schwarz, Alon, Burstein, Yigal, Diskin, Ron, Shakked, Zippora, Zimhony, Oren
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152951/ https://www.ncbi.nlm.nih.gov/pubmed/30248156 http://dx.doi.org/10.1371/journal.pone.0204457

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