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Use of sedative-hypnotics and the risk of Alzheimer’s dementia: A retrospective cohort study

There has been a growing interest in the relationship between sedative-hypnotics use and the risk of Alzheimer’s dementia (AD) risk. This study aimed to evaluate the risk of AD associated with the use of sedative-hypnotics. A retrospective cohort study was conducted with randomly selected 5% samples...

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Autores principales: Lee, Joonki, Jung, Sun Jae, Choi, Jae-won, Shin, Aesun, Lee, Yu Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152975/
https://www.ncbi.nlm.nih.gov/pubmed/30248129
http://dx.doi.org/10.1371/journal.pone.0204413
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author Lee, Joonki
Jung, Sun Jae
Choi, Jae-won
Shin, Aesun
Lee, Yu Jin
author_facet Lee, Joonki
Jung, Sun Jae
Choi, Jae-won
Shin, Aesun
Lee, Yu Jin
author_sort Lee, Joonki
collection PubMed
description There has been a growing interest in the relationship between sedative-hypnotics use and the risk of Alzheimer’s dementia (AD) risk. This study aimed to evaluate the risk of AD associated with the use of sedative-hypnotics. A retrospective cohort study was conducted with randomly selected 5% samples from ≥50 years old beneficiaries of National Health Insurance Service (NHIS) of Korea from January 2002 to December 2015. The exposure to sedative-hypnotics was defined when prescribed over 30 defined daily dose (DDD) after January 2004 and it was categorized by prescribed dosage, types and half-lives of benzodiazepines. Time-dependent Cox regression model with a lag period of 5-years was used to evaluate the association between use of sedative-hypnotics and the risk of subsequent AD. Sensitivity analysis was performed for restricting sedative-hypnotics only when prescribed with insomnia. A total of 268,170 subjects were identified and subjects exposed to sedative-hypnotics showed a higher risk of AD (HR: 1.79; 95% CI: 1.72–1.86) than those who were not. There was an increased risk of AD among subjects exposed to benzodiazepines or zolpidem (HR: 1.75; 95% CI: 1.67–1.82) and antidepressants or low-dose antipsychotics (HR: 1.63; 95% CI: 1.42–1.87). The risk of AD was increased regardless of dose of sedative-hypnotics and half-life among benzodiazepines, especially in exposure to more than 360 DDD of sedative-hypnotics (HR: 1.78; 95% CI: 1.60–1.99) and the long-acting benzodiazepine (HR:1.77; 95% CI: 1.65–1.89).
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spelling pubmed-61529752018-10-25 Use of sedative-hypnotics and the risk of Alzheimer’s dementia: A retrospective cohort study Lee, Joonki Jung, Sun Jae Choi, Jae-won Shin, Aesun Lee, Yu Jin PLoS One Research Article There has been a growing interest in the relationship between sedative-hypnotics use and the risk of Alzheimer’s dementia (AD) risk. This study aimed to evaluate the risk of AD associated with the use of sedative-hypnotics. A retrospective cohort study was conducted with randomly selected 5% samples from ≥50 years old beneficiaries of National Health Insurance Service (NHIS) of Korea from January 2002 to December 2015. The exposure to sedative-hypnotics was defined when prescribed over 30 defined daily dose (DDD) after January 2004 and it was categorized by prescribed dosage, types and half-lives of benzodiazepines. Time-dependent Cox regression model with a lag period of 5-years was used to evaluate the association between use of sedative-hypnotics and the risk of subsequent AD. Sensitivity analysis was performed for restricting sedative-hypnotics only when prescribed with insomnia. A total of 268,170 subjects were identified and subjects exposed to sedative-hypnotics showed a higher risk of AD (HR: 1.79; 95% CI: 1.72–1.86) than those who were not. There was an increased risk of AD among subjects exposed to benzodiazepines or zolpidem (HR: 1.75; 95% CI: 1.67–1.82) and antidepressants or low-dose antipsychotics (HR: 1.63; 95% CI: 1.42–1.87). The risk of AD was increased regardless of dose of sedative-hypnotics and half-life among benzodiazepines, especially in exposure to more than 360 DDD of sedative-hypnotics (HR: 1.78; 95% CI: 1.60–1.99) and the long-acting benzodiazepine (HR:1.77; 95% CI: 1.65–1.89). Public Library of Science 2018-09-24 /pmc/articles/PMC6152975/ /pubmed/30248129 http://dx.doi.org/10.1371/journal.pone.0204413 Text en © 2018 Lee et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Lee, Joonki
Jung, Sun Jae
Choi, Jae-won
Shin, Aesun
Lee, Yu Jin
Use of sedative-hypnotics and the risk of Alzheimer’s dementia: A retrospective cohort study
title Use of sedative-hypnotics and the risk of Alzheimer’s dementia: A retrospective cohort study
title_full Use of sedative-hypnotics and the risk of Alzheimer’s dementia: A retrospective cohort study
title_fullStr Use of sedative-hypnotics and the risk of Alzheimer’s dementia: A retrospective cohort study
title_full_unstemmed Use of sedative-hypnotics and the risk of Alzheimer’s dementia: A retrospective cohort study
title_short Use of sedative-hypnotics and the risk of Alzheimer’s dementia: A retrospective cohort study
title_sort use of sedative-hypnotics and the risk of alzheimer’s dementia: a retrospective cohort study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152975/
https://www.ncbi.nlm.nih.gov/pubmed/30248129
http://dx.doi.org/10.1371/journal.pone.0204413
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