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Robust activation of microhomology-mediated end joining for precision gene editing applications

One key problem in precision genome editing is the unpredictable plurality of sequence outcomes at the site of targeted DNA double stranded breaks (DSBs). This is due to the typical activation of the versatile Non-homologous End Joining (NHEJ) pathway. Such unpredictability limits the utility of som...

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Detalles Bibliográficos
Autores principales:	Ata, Hirotaka, Ekstrom, Thomas L., Martínez-Gálvez, Gabriel, Mann, Carla M., Dvornikov, Alexey V., Schaefbauer, Kyle J., Ma, Alvin C., Dobbs, Drena, Clark, Karl J., Ekker, Stephen C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152997/ https://www.ncbi.nlm.nih.gov/pubmed/30208061 http://dx.doi.org/10.1371/journal.pgen.1007652

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