Loss of Mecp2 Causes Atypical Synaptic and Molecular Plasticity of Parvalbumin-Expressing Interneurons Reflecting Rett Syndrome–Like Sensorimotor Defects

Rett syndrome (RTT) is caused in most cases by loss-of-function mutations in the X-linked gene encoding methyl CpG-binding protein 2 (MECP2). Understanding the pathological processes impacting sensory-motor control represents a major challenge for clinical management of individuals affected by RTT,...

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Detalles Bibliográficos
Autores principales: Morello, Noemi, Schina, Riccardo, Pilotto, Federica, Phillips, Mary, Melani, Riccardo, Plicato, Ornella, Pizzorusso, Tommaso, Pozzo-Miller, Lucas, Giustetto, Maurizio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Neuroscience 2018
Materias:
New Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6153339/
https://www.ncbi.nlm.nih.gov/pubmed/30255129
http://dx.doi.org/10.1523/ENEURO.0086-18.2018

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