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The New TNM Staging System for Thyroid Cancer and the Risk of Disease Downstaging
In October 2016 the American Joint Committee on Cancer (AJCC) published the 8th edition of the AJCC/TNM cancer staging system and it has been introduced in clinical practice since 1st January 2018. The effect of most of the changes in the new edition was the downstaging of a significant number of pa...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6153343/ https://www.ncbi.nlm.nih.gov/pubmed/30279679 http://dx.doi.org/10.3389/fendo.2018.00541 |
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author | Casella, Claudio Ministrini, Silvia Galani, Alessandro Mastriale, Francesco Cappelli, Carlo Portolani, Nazario |
author_facet | Casella, Claudio Ministrini, Silvia Galani, Alessandro Mastriale, Francesco Cappelli, Carlo Portolani, Nazario |
author_sort | Casella, Claudio |
collection | PubMed |
description | In October 2016 the American Joint Committee on Cancer (AJCC) published the 8th edition of the AJCC/TNM cancer staging system and it has been introduced in clinical practice since 1st January 2018. The effect of most of the changes in the new edition was the downstaging of a significant number of patients into lower stages, reflecting their low risk of thyroid cancer-related death. One of the most relevant modification refers to the role of the microscopic extra-thyroidal tumor invasion, which is no longer considered as criterion for the classification of T3 tumors. With the present study we want to assess the impact of the changes of the new staging system and therefore we analyzed or casistic of 84 T1-T3 thyroid-cancer patients. The results of our analysis show that he downstaging of patients according to the 8th TNM edition does not necessarily reflect less aggressive disease: we actually reported 2 lymph-nodal recurrences (40%) in the five patients that were downstaged from pT3 to pT2 and the lypmh-nodal recurrence rate for stage I rises from 0% with the 7th TNM edition to 5.3% with the 8th edition. |
format | Online Article Text |
id | pubmed-6153343 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-61533432018-10-02 The New TNM Staging System for Thyroid Cancer and the Risk of Disease Downstaging Casella, Claudio Ministrini, Silvia Galani, Alessandro Mastriale, Francesco Cappelli, Carlo Portolani, Nazario Front Endocrinol (Lausanne) Endocrinology In October 2016 the American Joint Committee on Cancer (AJCC) published the 8th edition of the AJCC/TNM cancer staging system and it has been introduced in clinical practice since 1st January 2018. The effect of most of the changes in the new edition was the downstaging of a significant number of patients into lower stages, reflecting their low risk of thyroid cancer-related death. One of the most relevant modification refers to the role of the microscopic extra-thyroidal tumor invasion, which is no longer considered as criterion for the classification of T3 tumors. With the present study we want to assess the impact of the changes of the new staging system and therefore we analyzed or casistic of 84 T1-T3 thyroid-cancer patients. The results of our analysis show that he downstaging of patients according to the 8th TNM edition does not necessarily reflect less aggressive disease: we actually reported 2 lymph-nodal recurrences (40%) in the five patients that were downstaged from pT3 to pT2 and the lypmh-nodal recurrence rate for stage I rises from 0% with the 7th TNM edition to 5.3% with the 8th edition. Frontiers Media S.A. 2018-09-18 /pmc/articles/PMC6153343/ /pubmed/30279679 http://dx.doi.org/10.3389/fendo.2018.00541 Text en Copyright © 2018 Casella, Ministrini, Galani, Mastriale, Cappelli and Portolani. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Endocrinology Casella, Claudio Ministrini, Silvia Galani, Alessandro Mastriale, Francesco Cappelli, Carlo Portolani, Nazario The New TNM Staging System for Thyroid Cancer and the Risk of Disease Downstaging |
title | The New TNM Staging System for Thyroid Cancer and the Risk of Disease Downstaging |
title_full | The New TNM Staging System for Thyroid Cancer and the Risk of Disease Downstaging |
title_fullStr | The New TNM Staging System for Thyroid Cancer and the Risk of Disease Downstaging |
title_full_unstemmed | The New TNM Staging System for Thyroid Cancer and the Risk of Disease Downstaging |
title_short | The New TNM Staging System for Thyroid Cancer and the Risk of Disease Downstaging |
title_sort | new tnm staging system for thyroid cancer and the risk of disease downstaging |
topic | Endocrinology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6153343/ https://www.ncbi.nlm.nih.gov/pubmed/30279679 http://dx.doi.org/10.3389/fendo.2018.00541 |
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