Cargando…

The New TNM Staging System for Thyroid Cancer and the Risk of Disease Downstaging

In October 2016 the American Joint Committee on Cancer (AJCC) published the 8th edition of the AJCC/TNM cancer staging system and it has been introduced in clinical practice since 1st January 2018. The effect of most of the changes in the new edition was the downstaging of a significant number of pa...

Descripción completa

Detalles Bibliográficos
Autores principales: Casella, Claudio, Ministrini, Silvia, Galani, Alessandro, Mastriale, Francesco, Cappelli, Carlo, Portolani, Nazario
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6153343/
https://www.ncbi.nlm.nih.gov/pubmed/30279679
http://dx.doi.org/10.3389/fendo.2018.00541
_version_ 1783357486648000512
author Casella, Claudio
Ministrini, Silvia
Galani, Alessandro
Mastriale, Francesco
Cappelli, Carlo
Portolani, Nazario
author_facet Casella, Claudio
Ministrini, Silvia
Galani, Alessandro
Mastriale, Francesco
Cappelli, Carlo
Portolani, Nazario
author_sort Casella, Claudio
collection PubMed
description In October 2016 the American Joint Committee on Cancer (AJCC) published the 8th edition of the AJCC/TNM cancer staging system and it has been introduced in clinical practice since 1st January 2018. The effect of most of the changes in the new edition was the downstaging of a significant number of patients into lower stages, reflecting their low risk of thyroid cancer-related death. One of the most relevant modification refers to the role of the microscopic extra-thyroidal tumor invasion, which is no longer considered as criterion for the classification of T3 tumors. With the present study we want to assess the impact of the changes of the new staging system and therefore we analyzed or casistic of 84 T1-T3 thyroid-cancer patients. The results of our analysis show that he downstaging of patients according to the 8th TNM edition does not necessarily reflect less aggressive disease: we actually reported 2 lymph-nodal recurrences (40%) in the five patients that were downstaged from pT3 to pT2 and the lypmh-nodal recurrence rate for stage I rises from 0% with the 7th TNM edition to 5.3% with the 8th edition.
format Online
Article
Text
id pubmed-6153343
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-61533432018-10-02 The New TNM Staging System for Thyroid Cancer and the Risk of Disease Downstaging Casella, Claudio Ministrini, Silvia Galani, Alessandro Mastriale, Francesco Cappelli, Carlo Portolani, Nazario Front Endocrinol (Lausanne) Endocrinology In October 2016 the American Joint Committee on Cancer (AJCC) published the 8th edition of the AJCC/TNM cancer staging system and it has been introduced in clinical practice since 1st January 2018. The effect of most of the changes in the new edition was the downstaging of a significant number of patients into lower stages, reflecting their low risk of thyroid cancer-related death. One of the most relevant modification refers to the role of the microscopic extra-thyroidal tumor invasion, which is no longer considered as criterion for the classification of T3 tumors. With the present study we want to assess the impact of the changes of the new staging system and therefore we analyzed or casistic of 84 T1-T3 thyroid-cancer patients. The results of our analysis show that he downstaging of patients according to the 8th TNM edition does not necessarily reflect less aggressive disease: we actually reported 2 lymph-nodal recurrences (40%) in the five patients that were downstaged from pT3 to pT2 and the lypmh-nodal recurrence rate for stage I rises from 0% with the 7th TNM edition to 5.3% with the 8th edition. Frontiers Media S.A. 2018-09-18 /pmc/articles/PMC6153343/ /pubmed/30279679 http://dx.doi.org/10.3389/fendo.2018.00541 Text en Copyright © 2018 Casella, Ministrini, Galani, Mastriale, Cappelli and Portolani. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Casella, Claudio
Ministrini, Silvia
Galani, Alessandro
Mastriale, Francesco
Cappelli, Carlo
Portolani, Nazario
The New TNM Staging System for Thyroid Cancer and the Risk of Disease Downstaging
title The New TNM Staging System for Thyroid Cancer and the Risk of Disease Downstaging
title_full The New TNM Staging System for Thyroid Cancer and the Risk of Disease Downstaging
title_fullStr The New TNM Staging System for Thyroid Cancer and the Risk of Disease Downstaging
title_full_unstemmed The New TNM Staging System for Thyroid Cancer and the Risk of Disease Downstaging
title_short The New TNM Staging System for Thyroid Cancer and the Risk of Disease Downstaging
title_sort new tnm staging system for thyroid cancer and the risk of disease downstaging
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6153343/
https://www.ncbi.nlm.nih.gov/pubmed/30279679
http://dx.doi.org/10.3389/fendo.2018.00541
work_keys_str_mv AT casellaclaudio thenewtnmstagingsystemforthyroidcancerandtheriskofdiseasedownstaging
AT ministrinisilvia thenewtnmstagingsystemforthyroidcancerandtheriskofdiseasedownstaging
AT galanialessandro thenewtnmstagingsystemforthyroidcancerandtheriskofdiseasedownstaging
AT mastrialefrancesco thenewtnmstagingsystemforthyroidcancerandtheriskofdiseasedownstaging
AT cappellicarlo thenewtnmstagingsystemforthyroidcancerandtheriskofdiseasedownstaging
AT portolaninazario thenewtnmstagingsystemforthyroidcancerandtheriskofdiseasedownstaging
AT casellaclaudio newtnmstagingsystemforthyroidcancerandtheriskofdiseasedownstaging
AT ministrinisilvia newtnmstagingsystemforthyroidcancerandtheriskofdiseasedownstaging
AT galanialessandro newtnmstagingsystemforthyroidcancerandtheriskofdiseasedownstaging
AT mastrialefrancesco newtnmstagingsystemforthyroidcancerandtheriskofdiseasedownstaging
AT cappellicarlo newtnmstagingsystemforthyroidcancerandtheriskofdiseasedownstaging
AT portolaninazario newtnmstagingsystemforthyroidcancerandtheriskofdiseasedownstaging