Cargando…
Gene expression profile and molecular pathway datasets resulting from benzo(a)pyrene exposure in the liver and testis of adult tilapia
Benzo(a)pyrene (BaP), the prototype of polycyclic aromatic hydrocarbons, is known to exhibits genotoxic and carcinogenic effects promoting molecular impacts. The dataset presented here is associated with the research article paper entitled “Transcriptome Analysis Reveals Novel Insights Into the Resp...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6153355/ https://www.ncbi.nlm.nih.gov/pubmed/30258954 http://dx.doi.org/10.1016/j.dib.2018.08.206 |
_version_ | 1783357489419386880 |
---|---|
author | Colli-Dula, Reyna Cristina Fang, Xiefan Moraga-Amador, David Albornoz-Abud, Nacira Zamora-Bustillos, Roberto Conesa, Ana Zapata-Perez, Omar Moreno, Diego Hernandez-Nuñez, Emanuel |
author_facet | Colli-Dula, Reyna Cristina Fang, Xiefan Moraga-Amador, David Albornoz-Abud, Nacira Zamora-Bustillos, Roberto Conesa, Ana Zapata-Perez, Omar Moreno, Diego Hernandez-Nuñez, Emanuel |
author_sort | Colli-Dula, Reyna Cristina |
collection | PubMed |
description | Benzo(a)pyrene (BaP), the prototype of polycyclic aromatic hydrocarbons, is known to exhibits genotoxic and carcinogenic effects promoting molecular impacts. The dataset presented here is associated with the research article paper entitled “Transcriptome Analysis Reveals Novel Insights Into the Response of Low-dose Benzo(a)pyrene Exposure in Male Tilapia”. In this article, we presented a transcriptomic characterization of male tilapia exposure to BaP in the short term. This data provides an extended analysis of changes in the gene expression and identification of pathways in the liver and testis of male tilapia exposure to BaP. We used gene set enrichment analysis (GSEA) and sub-network enrichment analysis (SNEA) to identify gene networks and pathways associated with molecular adverse effects of BaP exposure. The data indicates that target pathways related to promoting carcinogenesis such as DNA repair and DNA replication were affected as well as other crucial biological processes. Moreover, to determine whether some of the key reported genes of DNA damage are affected by BaP exposure, Quantitative PCR (qPCR) was performed. Gene set categories and sub-networks are provided and the corresponding signature differences from BaP exposure are listed. The information in these datasets may contribute to understanding the potential carcinogenesis mechanism of action from low BaP exposure. |
format | Online Article Text |
id | pubmed-6153355 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-61533552018-09-26 Gene expression profile and molecular pathway datasets resulting from benzo(a)pyrene exposure in the liver and testis of adult tilapia Colli-Dula, Reyna Cristina Fang, Xiefan Moraga-Amador, David Albornoz-Abud, Nacira Zamora-Bustillos, Roberto Conesa, Ana Zapata-Perez, Omar Moreno, Diego Hernandez-Nuñez, Emanuel Data Brief Genetics, Genomics and Molecular Biology Benzo(a)pyrene (BaP), the prototype of polycyclic aromatic hydrocarbons, is known to exhibits genotoxic and carcinogenic effects promoting molecular impacts. The dataset presented here is associated with the research article paper entitled “Transcriptome Analysis Reveals Novel Insights Into the Response of Low-dose Benzo(a)pyrene Exposure in Male Tilapia”. In this article, we presented a transcriptomic characterization of male tilapia exposure to BaP in the short term. This data provides an extended analysis of changes in the gene expression and identification of pathways in the liver and testis of male tilapia exposure to BaP. We used gene set enrichment analysis (GSEA) and sub-network enrichment analysis (SNEA) to identify gene networks and pathways associated with molecular adverse effects of BaP exposure. The data indicates that target pathways related to promoting carcinogenesis such as DNA repair and DNA replication were affected as well as other crucial biological processes. Moreover, to determine whether some of the key reported genes of DNA damage are affected by BaP exposure, Quantitative PCR (qPCR) was performed. Gene set categories and sub-networks are provided and the corresponding signature differences from BaP exposure are listed. The information in these datasets may contribute to understanding the potential carcinogenesis mechanism of action from low BaP exposure. Elsevier 2018-09-05 /pmc/articles/PMC6153355/ /pubmed/30258954 http://dx.doi.org/10.1016/j.dib.2018.08.206 Text en © 2018 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Genetics, Genomics and Molecular Biology Colli-Dula, Reyna Cristina Fang, Xiefan Moraga-Amador, David Albornoz-Abud, Nacira Zamora-Bustillos, Roberto Conesa, Ana Zapata-Perez, Omar Moreno, Diego Hernandez-Nuñez, Emanuel Gene expression profile and molecular pathway datasets resulting from benzo(a)pyrene exposure in the liver and testis of adult tilapia |
title | Gene expression profile and molecular pathway datasets resulting from benzo(a)pyrene exposure in the liver and testis of adult tilapia |
title_full | Gene expression profile and molecular pathway datasets resulting from benzo(a)pyrene exposure in the liver and testis of adult tilapia |
title_fullStr | Gene expression profile and molecular pathway datasets resulting from benzo(a)pyrene exposure in the liver and testis of adult tilapia |
title_full_unstemmed | Gene expression profile and molecular pathway datasets resulting from benzo(a)pyrene exposure in the liver and testis of adult tilapia |
title_short | Gene expression profile and molecular pathway datasets resulting from benzo(a)pyrene exposure in the liver and testis of adult tilapia |
title_sort | gene expression profile and molecular pathway datasets resulting from benzo(a)pyrene exposure in the liver and testis of adult tilapia |
topic | Genetics, Genomics and Molecular Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6153355/ https://www.ncbi.nlm.nih.gov/pubmed/30258954 http://dx.doi.org/10.1016/j.dib.2018.08.206 |
work_keys_str_mv | AT collidulareynacristina geneexpressionprofileandmolecularpathwaydatasetsresultingfrombenzoapyreneexposureintheliverandtestisofadulttilapia AT fangxiefan geneexpressionprofileandmolecularpathwaydatasetsresultingfrombenzoapyreneexposureintheliverandtestisofadulttilapia AT moragaamadordavid geneexpressionprofileandmolecularpathwaydatasetsresultingfrombenzoapyreneexposureintheliverandtestisofadulttilapia AT albornozabudnacira geneexpressionprofileandmolecularpathwaydatasetsresultingfrombenzoapyreneexposureintheliverandtestisofadulttilapia AT zamorabustillosroberto geneexpressionprofileandmolecularpathwaydatasetsresultingfrombenzoapyreneexposureintheliverandtestisofadulttilapia AT conesaana geneexpressionprofileandmolecularpathwaydatasetsresultingfrombenzoapyreneexposureintheliverandtestisofadulttilapia AT zapataperezomar geneexpressionprofileandmolecularpathwaydatasetsresultingfrombenzoapyreneexposureintheliverandtestisofadulttilapia AT morenodiego geneexpressionprofileandmolecularpathwaydatasetsresultingfrombenzoapyreneexposureintheliverandtestisofadulttilapia AT hernandeznunezemanuel geneexpressionprofileandmolecularpathwaydatasetsresultingfrombenzoapyreneexposureintheliverandtestisofadulttilapia |