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Structural and immunological characterization of E. coli derived recombinant CRM(197) protein used as carrier in conjugate vaccines

It is established that the immunogenicity of polysaccharides is enhanced by coupling them to carrier proteins. Cross reacting material (CRM(197)), a nontoxic variant of diphtheria toxin (DT) is widely used carrier protein for polysaccharide conjugate vaccines. Conventionally, CRM(197) is isolated by...

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Detalles Bibliográficos
Autores principales:	Mishra, Ravi P.N., Yadav, Ravi S.P., Jones, Christopher, Nocadello, Salvatore, Minasov, George, Shuvalova, Ludmilla A., Anderson, Wayne F., Goel, Akshay
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Portland Press Ltd. 2018
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6153374/ https://www.ncbi.nlm.nih.gov/pubmed/29875175 http://dx.doi.org/10.1042/BSR20180238

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