Cognitive and structural cerebral changes in amnestic mild cognitive impairment due to Alzheimer's disease after multicomponent training

INTRODUCTION: Information about how physical exercise affects patients with amnestic mild cognitive impairment (aMCI) due to Alzheimer's disease (AD) is still missing. This study evaluated the impact of multicomponent exercise training on cognition and brain structure in aMCI subjects with cere...

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Detalles Bibliográficos
Autores principales: Teixeira, Camila Vieira Ligo, Ribeiro de Rezende, Thiago Junqueira, Weiler, Marina, Magalhães, Thamires Naela Cardoso, Carletti-Cassani, Ana Flávia Mac Knight, Silva, Thiago Quinaglia Araújo Costa, Joaquim, Helena Passarelli Giroud, Talib, Leda Leme, Forlenza, Orestes Vicente, Franco, Mariana Pires, Nechio, Pedro Eduardo, Fernandes, Paula Teixeira, Cendes, Fernando, Balthazar, Marcio Luis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6153377/
https://www.ncbi.nlm.nih.gov/pubmed/30258976
http://dx.doi.org/10.1016/j.trci.2018.02.003
Descripción
Sumario:INTRODUCTION: Information about how physical exercise affects patients with amnestic mild cognitive impairment (aMCI) due to Alzheimer's disease (AD) is still missing. This study evaluated the impact of multicomponent exercise training on cognition and brain structure in aMCI subjects with cerebral spinal fluid positive AD biomarkers. METHODS: Forty aMCI subjects were divided in training (multicomponent exercise thrice a week for 6 months) and nontraining groups. Assessments included cardiorespiratory fitness, neurocognitive tests, and a structural magnetic resonance imaging using 3.0 T scanner. FreeSurfer software analyzed hippocampal volume and cortical thickness. RESULTS: The training group showed increased volume in both hippocampi and better performance in episodic memory test after 6 months. In contrast, the nontraining group declined in functional activities, recognition, and cardiorespiratory fitness for the same period. DISCUSSION: Multicomponent exercise seems to improve hippocampal volume and episodic memory, and maintains VO(2max) in aMCI due to AD.

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