Genetic and Epigenetic Perturbations by DNMT3A-R882 Mutants Impaired Apoptosis through Augmentation of PRDX2 in Myeloid Leukemia Cells

DNA methyltransferase 3A (DNMT3A) is mutated in various myeloid neoplasms including acute myeloid leukemia (AML), especially at the Arg882 and associated with inferior outcomes. Here, we report that the DNMT3A-Arg882His/Cys (R882H/C) mutations led to inactivation of apoptosis through DNA damage sign...

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Detalles Bibliográficos
Autores principales: Bera, Rabindranath, Chiu, Ming-Chun, Huang, Ying-Jung, Liang, Der-Cherng, Lee, Yun-Shien, Shih, Lee-Yung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2018
Materias:
Original article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6153424/
https://www.ncbi.nlm.nih.gov/pubmed/30245403
http://dx.doi.org/10.1016/j.neo.2018.08.013

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6153424/
https://www.ncbi.nlm.nih.gov/pubmed/30245403
http://dx.doi.org/10.1016/j.neo.2018.08.013

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