Cargando…

Elevated metabolic rate and skeletal muscle oxidative metabolism contribute to the reduced susceptibility of NF‐κB p50 null mice to obesity

Mice with a deletion of the p50 subunit of the proinflammatory nuclear factor kappa B pathway (NF‐κB p50) have reduced weight compared to wild‐type control mice. However, the physiological underpinning of this phenotype remains unknown. This study addressed this issue. Compared to littermate control...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bhatt, Bankim A., Dedousis, Nikolaos, Sipula, Ian J., O'Doherty, Robert M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2018
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6153426/ https://www.ncbi.nlm.nih.gov/pubmed/30251338 http://dx.doi.org/10.14814/phy2.13836

Ejemplares similares

Similar degrees of obesity induced by diet or aging cause strikingly different immunologic and metabolic outcomes
por: Krishna, Kanthi B., et al.
Publicado: (2016)

Mice Lacking NKT Cells but with a Complete Complement of CD8(+) T-Cells Are Not Protected against the Metabolic Abnormalities of Diet-Induced Obesity
por: Mantell, Benjamin S., et al.
Publicado: (2011)

Depletion of Liver Kupffer Cells Prevents the Development of Diet-Induced Hepatic Steatosis and Insulin Resistance
por: Huang, Wan, et al.
Publicado: (2010)

DNA methylation alters transcriptional rates of differentially expressed genes and contributes to pathophysiology in mice fed a high fat diet
por: Zhang, Pili, et al.
Publicado: (2017)

Hepatocyte-Specific Ablation or Whole-Body Inhibition of Xanthine Oxidoreductase in Mice Corrects Obesity-Induced Systemic Hyperuricemia Without Improving Metabolic Abnormalities
por: Harmon, Daniel B., et al.
Publicado: (2019)

Dendritic Cells Promote Macrophage Infiltration and Comprise a Substantial Proportion of Obesity-Associated Increases in CD11c(+) Cells in Adipose Tissue and Liver
por: Stefanovic-Racic, Maja, et al.
Publicado: (2012)

Parthenolide targets NF-κB (P50) to inhibit HIF-1α-mediated metabolic reprogramming of HCC
por: Liu, Xiaorong, et al.
Publicado: (2022)

Rescue of TRAF3-null mice by p100 NF-κB deficiency
por: He, Jeannie Q., et al.
Publicado: (2006)

Petite Integration Factor 1 (PIF1) helicase deficiency increases weight gain in Western diet-fed female mice without increased inflammatory markers or decreased glucose clearance
por: Belmonte, Frances R., et al.
Publicado: (2019)

Constitutive activation and overexpression of NF-κB/c-Rel in conjunction with p50 contribute to aggressive tongue tumorigenesis
por: Gupta, Shilpi, et al.
Publicado: (2018)

Reduction of aberrant NF-κB signalling ameliorates Rett syndrome phenotypes in Mecp2-null mice
por: Kishi, Noriyuki, et al.
Publicado: (2016)

Elevated Ca(2+) at the triad junction underlies dysregulation of Ca(2+) signaling in dysferlin-null skeletal muscle
por: Lukyanenko, Valeriy, et al.
Publicado: (2022)

Development of spontaneous neuropathy in NF-κBp50-deficient mice by calcineurin-signal involving impaired NF-κB activation
por: Nakamura-Yanagidaira, Tomoko, et al.
Publicado: (2011)

COVID-19 and Metabolic Syndrome: NF-κB Activation. Crossroads
por: Guisado-Vasco, Pablo, et al.
Publicado: (2020)

The levels of NF-κB p50 and NF-κB p65 play a role in thyroid carcinoma malignancy in vivo
por: Le, Fei, et al.
Publicado: (2018)

Predisposition to apoptosis in keratin 8-null liver is related to inactivation of NF-κB and SAPKs but not decreased c-Flip
por: Lee, Jongeun, et al.
Publicado: (2013)

BAG-1 interacts with the p50-p50 homodimeric NF-κB complex: implications for colorectal carcinogenesis
por: Southern, Samantha L., et al.
Publicado: (2011)

Chronic Inflammation and Susceptibility to Bacterial Infections in Mice Lacking the Polypeptide (p)105 Precursor (NF-κB1) but Expressing p50
por: Ishikawa, Hideaki, et al.
Publicado: (1998)

A homeostatic model of IκB metabolism to control constitutive NF-κB activity
por: O'Dea, Ellen L, et al.
Publicado: (2007)

Inflammatory cause of metabolic syndrome via brain stress and NF-κB
por: Cai, Dongsheng, et al.
Publicado: (2012)

The effects of pentoxifylline administration on NFΚB P50 transcription factor expression
por: Shamsara, Jamal, et al.
Publicado: (2012)

In Silico and In Vitro Screening of 50 Curcumin Compounds as EGFR and NF-κB Inhibitors
por: Saeed, Mohamed E. M., et al.
Publicado: (2022)

Rad50 promotes ovarian cancer progression through NF‐κB activation
por: Li, Yinuo, et al.
Publicado: (2021)

Obesity-induced elevated palmitic acid promotes inflammation and glucose metabolism disorders through GPRs/NF-κB/KLF7 pathway
por: Qiu, Tongtong, et al.
Publicado: (2022)

The regulation of sequence specific NF-κB DNA binding and transcription by IKKβ phosphorylation of NF-κB p50 at serine 80
por: Smith, Emma L, et al.
Publicado: (2019)

Elevated Mitochondrial Oxidative Stress Impairs Metabolic Adaptations to Exercise in Skeletal Muscle
por: Crane, Justin D., et al.
Publicado: (2013)

SUN-LB38 Adrenal Tumor Causing Unexplained Hyperhidrosis in a Young Man
por: Unterborn, Rebecca, et al.
Publicado: (2020)

Diaphoresis as the Prominent Manifestation of Pheochromocytoma
por: Unterborn, Rebecca, et al.
Publicado: (2021)

X-ray Crystallographic Study of Preferred Spacing by the NF-κB p50 Homodimer on κB DNA
por: Zhu, Norman, et al.
Publicado: (2023)

Regulation of the NF-κB-Mediated Transcription of Inflammatory Genes
por: Bhatt, Dev, et al.
Publicado: (2014)

NF-κB inducing kinase maintains T cell metabolic fitness in antitumor immunity
por: Gu, Meidi, et al.
Publicado: (2021)

NF-κB signaling in skeletal muscle: prospects for intervention in muscle diseases
por: Mourkioti, Foteini, et al.
Publicado: (2008)

SUN-675 Breast Cancer Treatment Causes Diabetes
por: Silparshetty, Santh V S, et al.
Publicado: (2020)

Expression of COX-2, NF-κB-p65, NF-κB-p50 and IKKα in malignant and adjacent normal human colorectal tissue
por: Charalambous, M P, et al.
Publicado: (2009)

GPRC6A Null Mice Exhibit Osteopenia, Feminization and Metabolic Syndrome
por: Pi, Min, et al.
Publicado: (2008)

Atmospheric Reaction Systems as Null-Models to Identify Structural Traces of Evolution in Metabolism
por: Holme, Petter, et al.
Publicado: (2011)

Dystrophin deficiency exacerbates skeletal muscle pathology in dysferlin-null mice
por: Han, Renzhi, et al.
Publicado: (2011)

Comparative proteomics of skeletal muscle mitochondria from myostatin-null mice
por: Puddick, Jonathan, et al.
Publicado: (2011)

Does sympathetic vasoconstriction contribute to metabolism: Perfusion matching in exercising skeletal muscle?
por: DeLorey, Darren S., et al.
Publicado: (2022)

The NF-κB p50:p50:HDAC-1 repressor complex orchestrates transcriptional inhibition of multiple pro-inflammatory genes
por: Elsharkawy, Ahmed M., et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_q1bsupqvororunrp6p9pf3arna