Targeting glutamine metabolism in PIK3CA mutant colorectal cancers

We recently reported that PIK3CA mutant colorectal cancers (CRCs) are addicted to glutamine through up-regulation of glutamate pyruvate transaminase 2 (GPT2). A GPT2 inhibitor suppresses in vivo growth of PIK3CA mutant, but not wild-type, CRCs. This study indicates that targeting glutamine may be an...

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Detalles Bibliográficos
Autores principales: Feng, Xiujing, Hao, Yujun, Wang, Zhenghe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Chongqing Medical University 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6153462/
https://www.ncbi.nlm.nih.gov/pubmed/30258894
http://dx.doi.org/10.1016/j.gendis.2016.09.001
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author Feng, Xiujing
Hao, Yujun
Wang, Zhenghe
author_facet Feng, Xiujing
Hao, Yujun
Wang, Zhenghe
author_sort Feng, Xiujing
collection PubMed
description We recently reported that PIK3CA mutant colorectal cancers (CRCs) are addicted to glutamine through up-regulation of glutamate pyruvate transaminase 2 (GPT2). A GPT2 inhibitor suppresses in vivo growth of PIK3CA mutant, but not wild-type, CRCs. This study indicates that targeting glutamine may be an effective approach to treat CRCs with PIK3CA mutations.
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spelling pubmed-61534622018-09-26 Targeting glutamine metabolism in PIK3CA mutant colorectal cancers Feng, Xiujing Hao, Yujun Wang, Zhenghe Genes Dis Article We recently reported that PIK3CA mutant colorectal cancers (CRCs) are addicted to glutamine through up-regulation of glutamate pyruvate transaminase 2 (GPT2). A GPT2 inhibitor suppresses in vivo growth of PIK3CA mutant, but not wild-type, CRCs. This study indicates that targeting glutamine may be an effective approach to treat CRCs with PIK3CA mutations. Chongqing Medical University 2016-09-10 /pmc/articles/PMC6153462/ /pubmed/30258894 http://dx.doi.org/10.1016/j.gendis.2016.09.001 Text en Copyright © 2016, Chongqing Medical University. Production and hosting by Elsevier B.V. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Feng, Xiujing
Hao, Yujun
Wang, Zhenghe
Targeting glutamine metabolism in PIK3CA mutant colorectal cancers
title Targeting glutamine metabolism in PIK3CA mutant colorectal cancers
title_full Targeting glutamine metabolism in PIK3CA mutant colorectal cancers
title_fullStr Targeting glutamine metabolism in PIK3CA mutant colorectal cancers
title_full_unstemmed Targeting glutamine metabolism in PIK3CA mutant colorectal cancers
title_short Targeting glutamine metabolism in PIK3CA mutant colorectal cancers
title_sort targeting glutamine metabolism in pik3ca mutant colorectal cancers
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6153462/
https://www.ncbi.nlm.nih.gov/pubmed/30258894
http://dx.doi.org/10.1016/j.gendis.2016.09.001
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AT haoyujun targetingglutaminemetabolisminpik3camutantcolorectalcancers
AT wangzhenghe targetingglutaminemetabolisminpik3camutantcolorectalcancers

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