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Proteasome inhibition and mechanism of resistance to a synthetic, library-based hexapeptide

Background The hexapeptide 4A6 (Ac-Thr(tBu)-His(Bzl)-Thr(Bzl)-Nle-Glu(OtBu)-Gly-Bza) was isolated from a peptide library constructed to identify peptide-based transport inhibitors of multidrug resistance (MDR) efflux pumps including P-glycoprotein and Multidrug Resistance-associated Protein 1. 4A6 p...

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Detalles Bibliográficos
Autores principales:	Oerlemans, Ruud, Berkers, Celia R., Assaraf, Yehuda G., Scheffer, George L., Peters, Godefridus J., Verbrugge, Sue Ellen, Cloos, Jacqueline, Slootstra, Jerry, Meloen, Rob H., Shoemaker, Robert H., Dijkmans, Ben A. C., Scheper, Rik J., Ovaa, Huib, Jansen, Gerrit
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer US 2018
Materias:	Preclinical Studies
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6153520/ https://www.ncbi.nlm.nih.gov/pubmed/29442210 http://dx.doi.org/10.1007/s10637-018-0569-x

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