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Rare-Earth-Doped Nanoparticles for Short-Wave Infrared Fluorescence Bioimaging and Molecular Targeting of α(V)β(3)-Expressing Tumors
The use of short-wave infrared (SWIR) light for fluorescence bioimaging offers the advantage of reduced photon scattering and improved tissue penetration compared to traditional shorter wavelength imaging approaches. While several nanomaterials have been shown capable of generating SWIR emissions, r...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6153542/ https://www.ncbi.nlm.nih.gov/pubmed/30246593 http://dx.doi.org/10.1177/1536012118799131 |
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author | Naczynski, Dominik Jan Stafford, Jason H. Türkcan, Silvan Jenkins, Cesare Koh, Ai Leen Sun, Conroy Xing, Lei |
author_facet | Naczynski, Dominik Jan Stafford, Jason H. Türkcan, Silvan Jenkins, Cesare Koh, Ai Leen Sun, Conroy Xing, Lei |
author_sort | Naczynski, Dominik Jan |
collection | PubMed |
description | The use of short-wave infrared (SWIR) light for fluorescence bioimaging offers the advantage of reduced photon scattering and improved tissue penetration compared to traditional shorter wavelength imaging approaches. While several nanomaterials have been shown capable of generating SWIR emissions, rare-earth-doped nanoparticles (REs) have emerged as an exceptionally bright and biocompatible class of SWIR emitters. Here, we demonstrate SWIR imaging of REs for several applications, including lymphatic mapping, real-time monitoring of probe biodistribution, and molecular targeting of the α(v)β(3) integrin in a tumor model. We further quantified the resolution and depth penetration limits of SWIR light emitted by REs in a customized imaging unit engineered for SWIR imaging of live small animals. Our results indicate that SWIR light has broad utility for preclinical biomedical imaging and demonstrates the potential for molecular imaging using targeted REs. |
format | Online Article Text |
id | pubmed-6153542 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-61535422018-09-27 Rare-Earth-Doped Nanoparticles for Short-Wave Infrared Fluorescence Bioimaging and Molecular Targeting of α(V)β(3)-Expressing Tumors Naczynski, Dominik Jan Stafford, Jason H. Türkcan, Silvan Jenkins, Cesare Koh, Ai Leen Sun, Conroy Xing, Lei Mol Imaging Brief Report The use of short-wave infrared (SWIR) light for fluorescence bioimaging offers the advantage of reduced photon scattering and improved tissue penetration compared to traditional shorter wavelength imaging approaches. While several nanomaterials have been shown capable of generating SWIR emissions, rare-earth-doped nanoparticles (REs) have emerged as an exceptionally bright and biocompatible class of SWIR emitters. Here, we demonstrate SWIR imaging of REs for several applications, including lymphatic mapping, real-time monitoring of probe biodistribution, and molecular targeting of the α(v)β(3) integrin in a tumor model. We further quantified the resolution and depth penetration limits of SWIR light emitted by REs in a customized imaging unit engineered for SWIR imaging of live small animals. Our results indicate that SWIR light has broad utility for preclinical biomedical imaging and demonstrates the potential for molecular imaging using targeted REs. SAGE Publications 2018-09-24 /pmc/articles/PMC6153542/ /pubmed/30246593 http://dx.doi.org/10.1177/1536012118799131 Text en © The Author(s) 2018 http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Brief Report Naczynski, Dominik Jan Stafford, Jason H. Türkcan, Silvan Jenkins, Cesare Koh, Ai Leen Sun, Conroy Xing, Lei Rare-Earth-Doped Nanoparticles for Short-Wave Infrared Fluorescence Bioimaging and Molecular Targeting of α(V)β(3)-Expressing Tumors |
title | Rare-Earth-Doped Nanoparticles for Short-Wave Infrared Fluorescence
Bioimaging and Molecular Targeting of α(V)β(3)-Expressing
Tumors |
title_full | Rare-Earth-Doped Nanoparticles for Short-Wave Infrared Fluorescence
Bioimaging and Molecular Targeting of α(V)β(3)-Expressing
Tumors |
title_fullStr | Rare-Earth-Doped Nanoparticles for Short-Wave Infrared Fluorescence
Bioimaging and Molecular Targeting of α(V)β(3)-Expressing
Tumors |
title_full_unstemmed | Rare-Earth-Doped Nanoparticles for Short-Wave Infrared Fluorescence
Bioimaging and Molecular Targeting of α(V)β(3)-Expressing
Tumors |
title_short | Rare-Earth-Doped Nanoparticles for Short-Wave Infrared Fluorescence
Bioimaging and Molecular Targeting of α(V)β(3)-Expressing
Tumors |
title_sort | rare-earth-doped nanoparticles for short-wave infrared fluorescence
bioimaging and molecular targeting of α(v)β(3)-expressing
tumors |
topic | Brief Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6153542/ https://www.ncbi.nlm.nih.gov/pubmed/30246593 http://dx.doi.org/10.1177/1536012118799131 |
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