Cargando…

FKBP5 expression in human adipose tissue: potential role in glucose and lipid metabolism, adipogenesis and type 2 diabetes

PURPOSE: Here, we explore the involvement of FKBP51 in glucocorticoid-induced insulin resistance (IR) in human subcutaneous adipose tissue (SAT), including its potential role in type 2 diabetes (T2D). Moreover, we assess the metabolic effects of reducing the activity of FKBP51 using the specific inh...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sidibeh, Cherno O., Pereira, Maria J., Abalo, Xesus M., J. Boersma, Gretha, Skrtic, Stanko, Lundkvist, Per, Katsogiannos, Petros, Hausch, Felix, Castillejo-López, Casimiro, Eriksson, Jan W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer US 2018
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6153563/ https://www.ncbi.nlm.nih.gov/pubmed/30032404 http://dx.doi.org/10.1007/s12020-018-1674-5

Ejemplares similares

Role of cannabinoid receptor 1 in human adipose tissue for lipolysis regulation and insulin resistance
por: Sidibeh, Cherno O., et al.
Publicado: (2016)

Role of peroxisome proliferator-activated receptor gamma Pro12Ala polymorphism in human adipose tissue: assessment of adipogenesis and adipocyte glucose and lipid turnover
por: Kamble, Prasad G., et al.
Publicado: (2018)

Proof-of-concept for CRISPR/Cas9 gene editing in human preadipocytes: Deletion of FKBP5 and PPARG and effects on adipocyte differentiation and metabolism
por: Kamble, Prasad G., et al.
Publicado: (2020)

The Many Faces of FKBP51
por: Hähle, Andreas, et al.
Publicado: (2019)

FKBP51 and FKBP12.6—Novel and tight interactors of Glomulin
por: Hähle, Andreas, et al.
Publicado: (2019)

FKBP Ligands—Where We Are and Where to Go?
por: Kolos, Jürgen M., et al.
Publicado: (2018)

Dapagliflozin once daily plus exenatide once weekly in obese adults without diabetes: Sustained reductions in body weight, glycaemia and blood pressure over 1 year
por: Lundkvist, Per, et al.
Publicado: (2017)

Modulating FKBP5/FKBP51 and autophagy lowers HTT (huntingtin) levels
por: Bailus, Barbara J., et al.
Publicado: (2021)

Development of NanoBRET‐Binding Assays for FKBP‐Ligand Profiling in Living Cells
por: Gnatzy, Monika T., et al.
Publicado: (2021)

Deletion of translin (Tsn) induces robust adiposity and hepatic steatosis without impairing glucose tolerance
por: Shah, Aparna P., et al.
Publicado: (2019)

The FKBP51 Inhibitor SAFit2 Restores the Pain-Relieving C16 Dihydroceramide after Nerve Injury
por: Wedel, Saskia, et al.
Publicado: (2022)

Response of multiple hormones to glucose and arginine challenge in T2DM after gastric bypass
por: Fanni, Giovanni, et al.
Publicado: (2022)

Pharmacological Modulation of the Psychiatric Risk Factor FKBP51 Alters Efficiency of Common Antidepressant Drugs
por: Pöhlmann, Max L., et al.
Publicado: (2018)

Sex differences in the effect of the FKBP5 inhibitor SAFit2 on anxiety and stress-induced reinstatement following cocaine self-administration
por: Connelly, Krista L., et al.
Publicado: (2020)

FKBP12 is a major regulator of ALK2 activity in multiple myeloma cells
por: Quist-Løkken, Ingrid, et al.
Publicado: (2023)

FKBP51 employs both scaffold and isomerase functions to promote NF-κB activation in melanoma
por: Romano, Simona, et al.
Publicado: (2015)

Stromal Vascular Cells and Adipogenesis: Cells within Adipose Depots Regulate Adipogenesis
por: Hausman, Gary J., et al.
Publicado: (2013)

Timcodar (VX-853) Is a Non-FKBP12 Binding Macrolide Derivative That Inhibits PPARγ and Suppresses Adipogenesis
por: Hinds, Terry D., et al.
Publicado: (2016)

Macrocyclic FKBP51 Ligands Define a Transient Binding Mode with Enhanced Selectivity
por: Voll, Andreas M., et al.
Publicado: (2021)

The stress regulator FKBP51: a novel and promising druggable target for the treatment of persistent pain states across sexes
por: Maiarù, Maria, et al.
Publicado: (2018)

A regulatory role for the co-chaperone FKBP51s in PD-L1 expression in glioma
por: D’Arrigo, Paolo, et al.
Publicado: (2017)

Time Course of Metabolic, Neuroendocrine, and Adipose Effects During 2 Years of Follow-up After Gastric Bypass in Patients With Type 2 Diabetes
por: Almby, Kristina E, et al.
Publicado: (2021)

Individual differences in the effects of prenatal stress exposure in rodents
por: Boersma, Gretha J., et al.
Publicado: (2014)

Adipogenesis: It Is Not Just Lipid That Comprises Adipose Tissue
por: Dodson, Michael V., et al.
Publicado: (2013)

Changes in Circulating Cytokines and Adipokines After RYGB in Patients with and without Type 2 Diabetes
por: Katsogiannos, Petros, et al.
Publicado: (2021)

Endothelial cells of adipose tissues: A niche of adipogenesis
por: Frontini, Andrea, et al.
Publicado: (2012)

Hyaluronan in adipogenesis, adipose tissue physiology and systemic metabolism
por: Zhu, Yi, et al.
Publicado: (2018)

Vitamin D regulation of adipogenesis and adipose tissue functions
por: Nimitphong, Hataikarn, et al.
Publicado: (2020)

RNA-Binding Proteins in the Regulation of Adipogenesis and Adipose Function
por: Zhang, Pengpeng, et al.
Publicado: (2022)

Quality of life after gastric bypass surgery in patients with type 2 diabetes: patients’ experiences during 2 years of follow-up
por: Katsogiannos, Petros, et al.
Publicado: (2020)

Stress-responsive FKBP51 regulates AKT2-AS160 signaling and metabolic function
por: Balsevich, Georgia, et al.
Publicado: (2017)

Biological Actions of the Hsp90-binding Immunophilins FKBP51 and FKBP52
por: Zgajnar, Nadia R., et al.
Publicado: (2019)

Interplay between Vitamin D and Adipose Tissue: Implications for Adipogenesis and Adipose Tissue Function
por: Lu, Shiqi, et al.
Publicado: (2023)

Silicon‐Enhanced Adipogenesis and Angiogenesis for Vascularized Adipose Tissue Engineering
por: Wang, Xiaoya, et al.
Publicado: (2018)

CircRNA-mediated regulation of brown adipose tissue adipogenesis
por: Liu, Kaiqing, et al.
Publicado: (2022)

Effectivity of (Personalized) Cognitive Behavioral Therapy for Insomnia in Mental Health Populations and the Elderly: An Overview
por: Mijnster, Teus, et al.
Publicado: (2022)

A New Anti-Depressive Strategy for the Elderly: Ablation of FKBP5/FKBP51
por: O'Leary, John C., et al.
Publicado: (2011)

FKBP52 and FKBP51 differentially regulate the stability of estrogen receptor in breast cancer
por: Habara, Makoto, et al.
Publicado: (2022)

The Dietary Antioxidant Piceatannol Inhibits Adipogenesis of Human Adipose Mesenchymal Stem Cells and Limits Glucose Transport and Lipogenic Activities in Adipocytes
por: Carpéné, Christian, et al.
Publicado: (2018)

Adipose Tissue Modification through Feeding Strategies and Their Implication on Adipogenesis and Adipose Tissue Metabolism in Ruminants
por: Urrutia, Olaia, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_8b9snmmg29ocmee3e1agthv5li