Distal Pancreatectomy with Celiac Axis Resection (DP-CAR) for Pancreatic Cancer. How I do It

Approximately 30% of all pancreatic cancer patients have locally advanced (AJCC stage 3) disease. A sub-group of these patients—where the cancer only involves the celiac axis—may benefit from distal pancreatectomy with celiac axis resection (DP-CAR). Previous studies have shown that DP-CAR offers a...

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Autores principales: Klompmaker, Sjors, Boggi, Ugo, Hackert, Thilo, Salvia, Roberto, Weiss, Matthew, Yamaue, Hiroki, Zeh, Herbert J., Besselink, Marc G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2018
Materias:
How I do it
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6153684/
https://www.ncbi.nlm.nih.gov/pubmed/30105677
http://dx.doi.org/10.1007/s11605-018-3894-7
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author Klompmaker, Sjors
Boggi, Ugo
Hackert, Thilo
Salvia, Roberto
Weiss, Matthew
Yamaue, Hiroki
Zeh, Herbert J.
Besselink, Marc G.
author_facet Klompmaker, Sjors
Boggi, Ugo
Hackert, Thilo
Salvia, Roberto
Weiss, Matthew
Yamaue, Hiroki
Zeh, Herbert J.
Besselink, Marc G.
author_sort Klompmaker, Sjors
collection PubMed
description Approximately 30% of all pancreatic cancer patients have locally advanced (AJCC stage 3) disease. A sub-group of these patients—where the cancer only involves the celiac axis—may benefit from distal pancreatectomy with celiac axis resection (DP-CAR). Previous studies have shown that DP-CAR offers a survival benefit to a selected group of patients with otherwise unresectable pancreatic cancer, when performed by experienced pancreatic cancer treatment teams at high-volume centers. This article proposes a standardized approach to DP-CAR, including routine neoadjuvant (FOLFIRINOX) chemotherapy. This approach to selecting patients and performing DP-CAR has the potential to improve short-term outcomes and overall survival in selected patients, but it should be reserved for high-volume centers.
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spelling pubmed-61536842018-10-04 Distal Pancreatectomy with Celiac Axis Resection (DP-CAR) for Pancreatic Cancer. How I do It Klompmaker, Sjors Boggi, Ugo Hackert, Thilo Salvia, Roberto Weiss, Matthew Yamaue, Hiroki Zeh, Herbert J. Besselink, Marc G. J Gastrointest Surg How I do it Approximately 30% of all pancreatic cancer patients have locally advanced (AJCC stage 3) disease. A sub-group of these patients—where the cancer only involves the celiac axis—may benefit from distal pancreatectomy with celiac axis resection (DP-CAR). Previous studies have shown that DP-CAR offers a survival benefit to a selected group of patients with otherwise unresectable pancreatic cancer, when performed by experienced pancreatic cancer treatment teams at high-volume centers. This article proposes a standardized approach to DP-CAR, including routine neoadjuvant (FOLFIRINOX) chemotherapy. This approach to selecting patients and performing DP-CAR has the potential to improve short-term outcomes and overall survival in selected patients, but it should be reserved for high-volume centers. Springer US 2018-08-13 2018 /pmc/articles/PMC6153684/ /pubmed/30105677 http://dx.doi.org/10.1007/s11605-018-3894-7 Text en © The Author(s) 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle How I do it
Klompmaker, Sjors
Boggi, Ugo
Hackert, Thilo
Salvia, Roberto
Weiss, Matthew
Yamaue, Hiroki
Zeh, Herbert J.
Besselink, Marc G.
Distal Pancreatectomy with Celiac Axis Resection (DP-CAR) for Pancreatic Cancer. How I do It
title Distal Pancreatectomy with Celiac Axis Resection (DP-CAR) for Pancreatic Cancer. How I do It
title_full Distal Pancreatectomy with Celiac Axis Resection (DP-CAR) for Pancreatic Cancer. How I do It
title_fullStr Distal Pancreatectomy with Celiac Axis Resection (DP-CAR) for Pancreatic Cancer. How I do It
title_full_unstemmed Distal Pancreatectomy with Celiac Axis Resection (DP-CAR) for Pancreatic Cancer. How I do It
title_short Distal Pancreatectomy with Celiac Axis Resection (DP-CAR) for Pancreatic Cancer. How I do It
title_sort distal pancreatectomy with celiac axis resection (dp-car) for pancreatic cancer. how i do it
topic How I do it
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6153684/
https://www.ncbi.nlm.nih.gov/pubmed/30105677
http://dx.doi.org/10.1007/s11605-018-3894-7
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