Endoplasmic Reticulum Stress Induces Myostatin High Molecular Weight Aggregates and Impairs Mature Myostatin Secretion

Sporadic inclusion body myositis (sIBM) is the most prevalent acquired muscle disorder in the elderly with no defined etiology or effective therapy. Endoplasmic reticulum stress and deposition of myostatin, a secreted negative regulator of muscle growth, have been implicated in disease pathology. Th...

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Detalles Bibliográficos
Autores principales: Sachdev, Rishibha, Kappes-Horn, Karin, Paulsen, Lydia, Duernberger, Yvonne, Pleschka, Catharina, Denner, Philip, Kundu, Bishwajit, Reimann, Jens, Vorberg, Ina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6153721/
https://www.ncbi.nlm.nih.gov/pubmed/29546591
http://dx.doi.org/10.1007/s12035-018-0997-9

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