Absence of K13 Polymorphism in Plasmodium falciparum from Brazilian Areas Where the Parasite Is Endemic

Plasmodium falciparum artemisinin-resistant parasites can be evaluated by examining polymorphisms in the kelch (PfK13) domain. A total of 69 samples from patients with falciparum malaria were analyzed. All samples were from areas in states in Brazil where the parasite was endemic: Acre (n = 14), Ama...

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Autores principales: Gomes, Larissa Rodrigues, Lavigne, Aline, Peterka, Cassio Leonel, Brasil, Patrícia, Ménard, Didier, Daniel-Ribeiro, Cláudio Tadeu, Ferreira-da-Cruz, Maria de Fátima
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2018
Materias:
Epidemiology and Surveillance
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6153804/
https://www.ncbi.nlm.nih.gov/pubmed/30061292
http://dx.doi.org/10.1128/AAC.00354-18
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author Gomes, Larissa Rodrigues
Lavigne, Aline
Peterka, Cassio Leonel
Brasil, Patrícia
Ménard, Didier
Daniel-Ribeiro, Cláudio Tadeu
Ferreira-da-Cruz, Maria de Fátima
author_facet Gomes, Larissa Rodrigues
Lavigne, Aline
Peterka, Cassio Leonel
Brasil, Patrícia
Ménard, Didier
Daniel-Ribeiro, Cláudio Tadeu
Ferreira-da-Cruz, Maria de Fátima
author_sort Gomes, Larissa Rodrigues
collection PubMed
description Plasmodium falciparum artemisinin-resistant parasites can be evaluated by examining polymorphisms in the kelch (PfK13) domain. A total of 69 samples from patients with falciparum malaria were analyzed. All samples were from areas in states in Brazil where the parasite was endemic: Acre (n = 14), Amapá (n = 15), Amazonas (n = 30), and Pará (n = 10). After DNA alignment with the 3D7 reference sequence, all samples were found to be wild type. These data provide a baseline for PfK13 and reinforce the pertinence of artemisinin combination therapy in Brazilian areas.
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spelling pubmed-61538042018-09-28 Absence of K13 Polymorphism in Plasmodium falciparum from Brazilian Areas Where the Parasite Is Endemic Gomes, Larissa Rodrigues Lavigne, Aline Peterka, Cassio Leonel Brasil, Patrícia Ménard, Didier Daniel-Ribeiro, Cláudio Tadeu Ferreira-da-Cruz, Maria de Fátima Antimicrob Agents Chemother Epidemiology and Surveillance Plasmodium falciparum artemisinin-resistant parasites can be evaluated by examining polymorphisms in the kelch (PfK13) domain. A total of 69 samples from patients with falciparum malaria were analyzed. All samples were from areas in states in Brazil where the parasite was endemic: Acre (n = 14), Amapá (n = 15), Amazonas (n = 30), and Pará (n = 10). After DNA alignment with the 3D7 reference sequence, all samples were found to be wild type. These data provide a baseline for PfK13 and reinforce the pertinence of artemisinin combination therapy in Brazilian areas. American Society for Microbiology 2018-09-24 /pmc/articles/PMC6153804/ /pubmed/30061292 http://dx.doi.org/10.1128/AAC.00354-18 Text en Copyright © 2018 Gomes et al. https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Epidemiology and Surveillance
Gomes, Larissa Rodrigues
Lavigne, Aline
Peterka, Cassio Leonel
Brasil, Patrícia
Ménard, Didier
Daniel-Ribeiro, Cláudio Tadeu
Ferreira-da-Cruz, Maria de Fátima
Absence of K13 Polymorphism in Plasmodium falciparum from Brazilian Areas Where the Parasite Is Endemic
title Absence of K13 Polymorphism in Plasmodium falciparum from Brazilian Areas Where the Parasite Is Endemic
title_full Absence of K13 Polymorphism in Plasmodium falciparum from Brazilian Areas Where the Parasite Is Endemic
title_fullStr Absence of K13 Polymorphism in Plasmodium falciparum from Brazilian Areas Where the Parasite Is Endemic
title_full_unstemmed Absence of K13 Polymorphism in Plasmodium falciparum from Brazilian Areas Where the Parasite Is Endemic
title_short Absence of K13 Polymorphism in Plasmodium falciparum from Brazilian Areas Where the Parasite Is Endemic
title_sort absence of k13 polymorphism in plasmodium falciparum from brazilian areas where the parasite is endemic
topic Epidemiology and Surveillance
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6153804/
https://www.ncbi.nlm.nih.gov/pubmed/30061292
http://dx.doi.org/10.1128/AAC.00354-18
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