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Role of Serological Tests in the Diagnosis of Mold Infections

PURPOSE OF REVIEW: To understand the role of antibody detection in the diagnosis of infections caused by filamentous fungi (molds). Rapid and accurate profiling of infection-causing fungal pathogens remains a significant challenge in modern health care. Classical fungal culture and serology continue...

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Detalles Bibliográficos
Autores principales: Richardson, Malcolm, Page, Iain
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6153857/
https://www.ncbi.nlm.nih.gov/pubmed/30294405
http://dx.doi.org/10.1007/s12281-018-0321-1
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author Richardson, Malcolm
Page, Iain
author_facet Richardson, Malcolm
Page, Iain
author_sort Richardson, Malcolm
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description PURPOSE OF REVIEW: To understand the role of antibody detection in the diagnosis of infections caused by filamentous fungi (molds). Rapid and accurate profiling of infection-causing fungal pathogens remains a significant challenge in modern health care. Classical fungal culture and serology continue to be relevant even though over the past few decades, antigen (biomarker) assays such as ELISA and lateral flow devices have been developed and validated. RECENT FINDINGS: This article reviews the current antibody detection systems (serological tests) for the diagnosis of mold infections associated with pulmonary disease and introduces new developments. Classic and more recently developed serological techniques and their performance characteristics, including immunodiffusion, complement fixation, and ELISA. SUMMARY: The diseases covered are allergic bronchopulmonary aspergillosis, chronic pulmonary aspergillosis, invasive aspergillosis, mucormycosis, diseases caused by filamentous basidiomycetes, infection caused by Talaromyces marneffei and pythiosis. Serology remains a cornerstone for fungal diagnostic testing.
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spelling pubmed-61538572018-10-04 Role of Serological Tests in the Diagnosis of Mold Infections Richardson, Malcolm Page, Iain Curr Fungal Infect Rep Advances in Diagnosis of Invasive Fungal Infections (S Chen, Section Editor) PURPOSE OF REVIEW: To understand the role of antibody detection in the diagnosis of infections caused by filamentous fungi (molds). Rapid and accurate profiling of infection-causing fungal pathogens remains a significant challenge in modern health care. Classical fungal culture and serology continue to be relevant even though over the past few decades, antigen (biomarker) assays such as ELISA and lateral flow devices have been developed and validated. RECENT FINDINGS: This article reviews the current antibody detection systems (serological tests) for the diagnosis of mold infections associated with pulmonary disease and introduces new developments. Classic and more recently developed serological techniques and their performance characteristics, including immunodiffusion, complement fixation, and ELISA. SUMMARY: The diseases covered are allergic bronchopulmonary aspergillosis, chronic pulmonary aspergillosis, invasive aspergillosis, mucormycosis, diseases caused by filamentous basidiomycetes, infection caused by Talaromyces marneffei and pythiosis. Serology remains a cornerstone for fungal diagnostic testing. Springer US 2018-09-05 2018 /pmc/articles/PMC6153857/ /pubmed/30294405 http://dx.doi.org/10.1007/s12281-018-0321-1 Text en © The Author(s) 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Advances in Diagnosis of Invasive Fungal Infections (S Chen, Section Editor)
Richardson, Malcolm
Page, Iain
Role of Serological Tests in the Diagnosis of Mold Infections
title Role of Serological Tests in the Diagnosis of Mold Infections
title_full Role of Serological Tests in the Diagnosis of Mold Infections
title_fullStr Role of Serological Tests in the Diagnosis of Mold Infections
title_full_unstemmed Role of Serological Tests in the Diagnosis of Mold Infections
title_short Role of Serological Tests in the Diagnosis of Mold Infections
title_sort role of serological tests in the diagnosis of mold infections
topic Advances in Diagnosis of Invasive Fungal Infections (S Chen, Section Editor)
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6153857/
https://www.ncbi.nlm.nih.gov/pubmed/30294405
http://dx.doi.org/10.1007/s12281-018-0321-1
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