Cargando…
Role of Serological Tests in the Diagnosis of Mold Infections
PURPOSE OF REVIEW: To understand the role of antibody detection in the diagnosis of infections caused by filamentous fungi (molds). Rapid and accurate profiling of infection-causing fungal pathogens remains a significant challenge in modern health care. Classical fungal culture and serology continue...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer US
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6153857/ https://www.ncbi.nlm.nih.gov/pubmed/30294405 http://dx.doi.org/10.1007/s12281-018-0321-1 |
_version_ | 1783357577428467712 |
---|---|
author | Richardson, Malcolm Page, Iain |
author_facet | Richardson, Malcolm Page, Iain |
author_sort | Richardson, Malcolm |
collection | PubMed |
description | PURPOSE OF REVIEW: To understand the role of antibody detection in the diagnosis of infections caused by filamentous fungi (molds). Rapid and accurate profiling of infection-causing fungal pathogens remains a significant challenge in modern health care. Classical fungal culture and serology continue to be relevant even though over the past few decades, antigen (biomarker) assays such as ELISA and lateral flow devices have been developed and validated. RECENT FINDINGS: This article reviews the current antibody detection systems (serological tests) for the diagnosis of mold infections associated with pulmonary disease and introduces new developments. Classic and more recently developed serological techniques and their performance characteristics, including immunodiffusion, complement fixation, and ELISA. SUMMARY: The diseases covered are allergic bronchopulmonary aspergillosis, chronic pulmonary aspergillosis, invasive aspergillosis, mucormycosis, diseases caused by filamentous basidiomycetes, infection caused by Talaromyces marneffei and pythiosis. Serology remains a cornerstone for fungal diagnostic testing. |
format | Online Article Text |
id | pubmed-6153857 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Springer US |
record_format | MEDLINE/PubMed |
spelling | pubmed-61538572018-10-04 Role of Serological Tests in the Diagnosis of Mold Infections Richardson, Malcolm Page, Iain Curr Fungal Infect Rep Advances in Diagnosis of Invasive Fungal Infections (S Chen, Section Editor) PURPOSE OF REVIEW: To understand the role of antibody detection in the diagnosis of infections caused by filamentous fungi (molds). Rapid and accurate profiling of infection-causing fungal pathogens remains a significant challenge in modern health care. Classical fungal culture and serology continue to be relevant even though over the past few decades, antigen (biomarker) assays such as ELISA and lateral flow devices have been developed and validated. RECENT FINDINGS: This article reviews the current antibody detection systems (serological tests) for the diagnosis of mold infections associated with pulmonary disease and introduces new developments. Classic and more recently developed serological techniques and their performance characteristics, including immunodiffusion, complement fixation, and ELISA. SUMMARY: The diseases covered are allergic bronchopulmonary aspergillosis, chronic pulmonary aspergillosis, invasive aspergillosis, mucormycosis, diseases caused by filamentous basidiomycetes, infection caused by Talaromyces marneffei and pythiosis. Serology remains a cornerstone for fungal diagnostic testing. Springer US 2018-09-05 2018 /pmc/articles/PMC6153857/ /pubmed/30294405 http://dx.doi.org/10.1007/s12281-018-0321-1 Text en © The Author(s) 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Advances in Diagnosis of Invasive Fungal Infections (S Chen, Section Editor) Richardson, Malcolm Page, Iain Role of Serological Tests in the Diagnosis of Mold Infections |
title | Role of Serological Tests in the Diagnosis of Mold Infections |
title_full | Role of Serological Tests in the Diagnosis of Mold Infections |
title_fullStr | Role of Serological Tests in the Diagnosis of Mold Infections |
title_full_unstemmed | Role of Serological Tests in the Diagnosis of Mold Infections |
title_short | Role of Serological Tests in the Diagnosis of Mold Infections |
title_sort | role of serological tests in the diagnosis of mold infections |
topic | Advances in Diagnosis of Invasive Fungal Infections (S Chen, Section Editor) |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6153857/ https://www.ncbi.nlm.nih.gov/pubmed/30294405 http://dx.doi.org/10.1007/s12281-018-0321-1 |
work_keys_str_mv | AT richardsonmalcolm roleofserologicaltestsinthediagnosisofmoldinfections AT pageiain roleofserologicaltestsinthediagnosisofmoldinfections |