Modification of Natural Eudesmane Scaffolds via Mizoroki-Heck Reactions

The Mizoroki-Heck reaction was applied to substrates derived from isocostic and ilicic acids, important sesquiterpene components of Dittrichia viscosa L. Greuter that were extracted directly from plant material collected in Morocco. After optimization of the metallo-catalysis conditions, various ary...

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Detalles Bibliográficos
Autores principales: Zaki, Mohamed, Akssira, Mohamed, Berteina-Raboin, Sabine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6153938/
https://www.ncbi.nlm.nih.gov/pubmed/28425951
http://dx.doi.org/10.3390/molecules22040652
Descripción
Sumario:The Mizoroki-Heck reaction was applied to substrates derived from isocostic and ilicic acids, important sesquiterpene components of Dittrichia viscosa L. Greuter that were extracted directly from plant material collected in Morocco. After optimization of the metallo-catalysis conditions, various aryl-groups were successfully introduced on the exocyclic double bond with an exclusive E-configuration and without racemization.

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