The Effect of Food on Tramadol and Celecoxib Bioavailability Following Oral Administration of Co-Crystal of Tramadol–Celecoxib (CTC): A Randomised, Open-Label, Single-Dose, Crossover Study in Healthy Volunteers

BACKGROUND AND OBJECTIVE: Co-Crystal of Tramadol–Celecoxib (CTC), in development for the treatment of moderate to severe acute pain, is a first-in-class co-crystal containing a 1:1 molecular ratio of two active pharmaceutical ingredients; rac-tramadol·HCl and celecoxib. This randomised, open-label,...

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Detalles Bibliográficos
Autores principales: Encina, Gregorio, Encabo, Mercedes, Escriche, Marisol, Lahjou, Mounia, Sicard, Eric, Smith, Kevin, Gascon, Neus, Plata-Salamán, Carlos, Videla, Sebastián
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2018
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6153956/
https://www.ncbi.nlm.nih.gov/pubmed/30008052
http://dx.doi.org/10.1007/s40261-018-0672-y

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