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New Acorane-Type Sesquiterpene from Acorus calamus L.
A new sesquiterpene, named neo-acorane A (1), and two known ones, acoric acid (2) and calamusin D (3), were isolated from a 95% ethanol extract of the rhizome parts of Acorus calamus L. Their structures were elucidated by spectroscopic methods, and the absolute configurations were determined by sing...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6153993/ https://www.ncbi.nlm.nih.gov/pubmed/28346359 http://dx.doi.org/10.3390/molecules22040529 |
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author | Li, Juan Zhao, Jianping Wang, Wei Li, Lin Zhang, Lan Zhao, Xiao-Fang Liu, Qing-Ru Liu, Fang Yang, Min Khan, Ikhlas A. Li, Shun-Xiang |
author_facet | Li, Juan Zhao, Jianping Wang, Wei Li, Lin Zhang, Lan Zhao, Xiao-Fang Liu, Qing-Ru Liu, Fang Yang, Min Khan, Ikhlas A. Li, Shun-Xiang |
author_sort | Li, Juan |
collection | PubMed |
description | A new sesquiterpene, named neo-acorane A (1), and two known ones, acoric acid (2) and calamusin D (3), were isolated from a 95% ethanol extract of the rhizome parts of Acorus calamus L. Their structures were elucidated by spectroscopic methods, and the absolute configurations were determined by single-crystal X-ray diffraction analysis. Compounds 1 and 2 are nonisoprenoid sesquiterpenoids, likely biosynthesized from an acorane-type sesquiterpene by oxidative fission of the six- or five-membered ring. Moreover, compounds 1 (10 μM), 2 (5 μM and 10 μM) and 3 (10 μM) showed cell proliferation activity on the SK-N-BE (2) cell line. |
format | Online Article Text |
id | pubmed-6153993 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-61539932018-11-13 New Acorane-Type Sesquiterpene from Acorus calamus L. Li, Juan Zhao, Jianping Wang, Wei Li, Lin Zhang, Lan Zhao, Xiao-Fang Liu, Qing-Ru Liu, Fang Yang, Min Khan, Ikhlas A. Li, Shun-Xiang Molecules Article A new sesquiterpene, named neo-acorane A (1), and two known ones, acoric acid (2) and calamusin D (3), were isolated from a 95% ethanol extract of the rhizome parts of Acorus calamus L. Their structures were elucidated by spectroscopic methods, and the absolute configurations were determined by single-crystal X-ray diffraction analysis. Compounds 1 and 2 are nonisoprenoid sesquiterpenoids, likely biosynthesized from an acorane-type sesquiterpene by oxidative fission of the six- or five-membered ring. Moreover, compounds 1 (10 μM), 2 (5 μM and 10 μM) and 3 (10 μM) showed cell proliferation activity on the SK-N-BE (2) cell line. MDPI 2017-03-26 /pmc/articles/PMC6153993/ /pubmed/28346359 http://dx.doi.org/10.3390/molecules22040529 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Li, Juan Zhao, Jianping Wang, Wei Li, Lin Zhang, Lan Zhao, Xiao-Fang Liu, Qing-Ru Liu, Fang Yang, Min Khan, Ikhlas A. Li, Shun-Xiang New Acorane-Type Sesquiterpene from Acorus calamus L. |
title | New Acorane-Type Sesquiterpene from Acorus
calamus L. |
title_full | New Acorane-Type Sesquiterpene from Acorus
calamus L. |
title_fullStr | New Acorane-Type Sesquiterpene from Acorus
calamus L. |
title_full_unstemmed | New Acorane-Type Sesquiterpene from Acorus
calamus L. |
title_short | New Acorane-Type Sesquiterpene from Acorus
calamus L. |
title_sort | new acorane-type sesquiterpene from acorus
calamus l. |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6153993/ https://www.ncbi.nlm.nih.gov/pubmed/28346359 http://dx.doi.org/10.3390/molecules22040529 |
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