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New Acorane-Type Sesquiterpene from Acorus calamus L.

A new sesquiterpene, named neo-acorane A (1), and two known ones, acoric acid (2) and calamusin D (3), were isolated from a 95% ethanol extract of the rhizome parts of Acorus calamus L. Their structures were elucidated by spectroscopic methods, and the absolute configurations were determined by sing...

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Autores principales: Li, Juan, Zhao, Jianping, Wang, Wei, Li, Lin, Zhang, Lan, Zhao, Xiao-Fang, Liu, Qing-Ru, Liu, Fang, Yang, Min, Khan, Ikhlas A., Li, Shun-Xiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6153993/
https://www.ncbi.nlm.nih.gov/pubmed/28346359
http://dx.doi.org/10.3390/molecules22040529
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author Li, Juan
Zhao, Jianping
Wang, Wei
Li, Lin
Zhang, Lan
Zhao, Xiao-Fang
Liu, Qing-Ru
Liu, Fang
Yang, Min
Khan, Ikhlas A.
Li, Shun-Xiang
author_facet Li, Juan
Zhao, Jianping
Wang, Wei
Li, Lin
Zhang, Lan
Zhao, Xiao-Fang
Liu, Qing-Ru
Liu, Fang
Yang, Min
Khan, Ikhlas A.
Li, Shun-Xiang
author_sort Li, Juan
collection PubMed
description A new sesquiterpene, named neo-acorane A (1), and two known ones, acoric acid (2) and calamusin D (3), were isolated from a 95% ethanol extract of the rhizome parts of Acorus calamus L. Their structures were elucidated by spectroscopic methods, and the absolute configurations were determined by single-crystal X-ray diffraction analysis. Compounds 1 and 2 are nonisoprenoid sesquiterpenoids, likely biosynthesized from an acorane-type sesquiterpene by oxidative fission of the six- or five-membered ring. Moreover, compounds 1 (10 μM), 2 (5 μM and 10 μM) and 3 (10 μM) showed cell proliferation activity on the SK-N-BE (2) cell line.
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spelling pubmed-61539932018-11-13 New Acorane-Type Sesquiterpene from Acorus calamus L. Li, Juan Zhao, Jianping Wang, Wei Li, Lin Zhang, Lan Zhao, Xiao-Fang Liu, Qing-Ru Liu, Fang Yang, Min Khan, Ikhlas A. Li, Shun-Xiang Molecules Article A new sesquiterpene, named neo-acorane A (1), and two known ones, acoric acid (2) and calamusin D (3), were isolated from a 95% ethanol extract of the rhizome parts of Acorus calamus L. Their structures were elucidated by spectroscopic methods, and the absolute configurations were determined by single-crystal X-ray diffraction analysis. Compounds 1 and 2 are nonisoprenoid sesquiterpenoids, likely biosynthesized from an acorane-type sesquiterpene by oxidative fission of the six- or five-membered ring. Moreover, compounds 1 (10 μM), 2 (5 μM and 10 μM) and 3 (10 μM) showed cell proliferation activity on the SK-N-BE (2) cell line. MDPI 2017-03-26 /pmc/articles/PMC6153993/ /pubmed/28346359 http://dx.doi.org/10.3390/molecules22040529 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Li, Juan
Zhao, Jianping
Wang, Wei
Li, Lin
Zhang, Lan
Zhao, Xiao-Fang
Liu, Qing-Ru
Liu, Fang
Yang, Min
Khan, Ikhlas A.
Li, Shun-Xiang
New Acorane-Type Sesquiterpene from Acorus calamus L.
title New Acorane-Type Sesquiterpene from Acorus calamus L.
title_full New Acorane-Type Sesquiterpene from Acorus calamus L.
title_fullStr New Acorane-Type Sesquiterpene from Acorus calamus L.
title_full_unstemmed New Acorane-Type Sesquiterpene from Acorus calamus L.
title_short New Acorane-Type Sesquiterpene from Acorus calamus L.
title_sort new acorane-type sesquiterpene from acorus calamus l.
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6153993/
https://www.ncbi.nlm.nih.gov/pubmed/28346359
http://dx.doi.org/10.3390/molecules22040529
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