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SUMO-Targeted Ubiquitin Ligases (STUbLs) Reduce the Toxicity and Abnormal Transcriptional Activity Associated With a Mutant, Aggregation-Prone Fragment of Huntingtin

Cell viability and gene expression profiles are altered in cellular models of neurodegenerative disorders such as Huntington’s Disease (HD). Using the yeast model system, we show that the SUMO-targeted ubiquitin ligase (STUbL) Slx5 reduces the toxicity and abnormal transcriptional activity associate...

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Detalles Bibliográficos
Autores principales:	Ohkuni, Kentaro, Pasupala, Nagesh, Peek, Jennifer, Holloway, Grace Lauren, Sclar, Gloria D., Levy-Myers, Reuben, Baker, Richard E., Basrai, Munira A., Kerscher, Oliver
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Genetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154015/ https://www.ncbi.nlm.nih.gov/pubmed/30279700 http://dx.doi.org/10.3389/fgene.2018.00379

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