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T Cells on Engineered Substrates: The Impact of TCR Clustering Is Enhanced by LFA-1 Engagement

We created APC-mimetic synthetic substrates to study the impact of ligand clustering on T cell activation and spreading. The substrates exhibit antibodies directed against the TCR-complex in the form of a patterned array of sub micrometric dots surrounded by a fluid supported lipid bilayer (SLB) whi...

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Detalles Bibliográficos
Autores principales:	Benard, Emmanuelle, Nunès, Jacques A., Limozin, Laurent, Sengupta, Kheya
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154019/ https://www.ncbi.nlm.nih.gov/pubmed/30279692 http://dx.doi.org/10.3389/fimmu.2018.02085

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