The Structure–Antioxidant Activity Relationship of Ferulates

The antioxidant activity of ferulic acid (1), iso-ferulic acid (2), coniferyl aldehyde (3), methyl ferulate (4), and ethyl ferulate (5) were investigated using 2,2′-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) and ferric-reducing antioxidant power (FRAP) assays and autoxidation of triacy...

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Autores principales: Karamać, Magdalena, Koleva, Lidiya, Kancheva, Vessela D., Amarowicz, Ryszard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154093/
https://www.ncbi.nlm.nih.gov/pubmed/28346342
http://dx.doi.org/10.3390/molecules22040527
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author Karamać, Magdalena
Koleva, Lidiya
Kancheva, Vessela D.
Amarowicz, Ryszard
author_facet Karamać, Magdalena
Koleva, Lidiya
Kancheva, Vessela D.
Amarowicz, Ryszard
author_sort Karamać, Magdalena
collection PubMed
description The antioxidant activity of ferulic acid (1), iso-ferulic acid (2), coniferyl aldehyde (3), methyl ferulate (4), and ethyl ferulate (5) were investigated using 2,2′-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) and ferric-reducing antioxidant power (FRAP) assays and autoxidation of triacylglycerols of commercially available sunflower oil (TGSO). The compounds tested for ability to scavenge ABTS radical cations was in the order of ferulic acid > coniferyl aldehyde ≈ iso-ferulic acid > ethyl ferulate ≈ methyl ferulate. The results of the FRAP assay for ferulic acid, iso-ferulic acid, and coniferyl aldehyde were similar to and higher than those of methyl ferulate and ethyl ferulate. In the lipid system, iso-ferulic acid showed weak antioxidant activity. The other ferulates exhibited much stronger, yet similar, activities.
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spelling pubmed-61540932018-11-13 The Structure–Antioxidant Activity Relationship of Ferulates Karamać, Magdalena Koleva, Lidiya Kancheva, Vessela D. Amarowicz, Ryszard Molecules Article The antioxidant activity of ferulic acid (1), iso-ferulic acid (2), coniferyl aldehyde (3), methyl ferulate (4), and ethyl ferulate (5) were investigated using 2,2′-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) and ferric-reducing antioxidant power (FRAP) assays and autoxidation of triacylglycerols of commercially available sunflower oil (TGSO). The compounds tested for ability to scavenge ABTS radical cations was in the order of ferulic acid > coniferyl aldehyde ≈ iso-ferulic acid > ethyl ferulate ≈ methyl ferulate. The results of the FRAP assay for ferulic acid, iso-ferulic acid, and coniferyl aldehyde were similar to and higher than those of methyl ferulate and ethyl ferulate. In the lipid system, iso-ferulic acid showed weak antioxidant activity. The other ferulates exhibited much stronger, yet similar, activities. MDPI 2017-03-25 /pmc/articles/PMC6154093/ /pubmed/28346342 http://dx.doi.org/10.3390/molecules22040527 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Karamać, Magdalena
Koleva, Lidiya
Kancheva, Vessela D.
Amarowicz, Ryszard
The Structure–Antioxidant Activity Relationship of Ferulates
title The Structure–Antioxidant Activity Relationship of Ferulates
title_full The Structure–Antioxidant Activity Relationship of Ferulates
title_fullStr The Structure–Antioxidant Activity Relationship of Ferulates
title_full_unstemmed The Structure–Antioxidant Activity Relationship of Ferulates
title_short The Structure–Antioxidant Activity Relationship of Ferulates
title_sort structure–antioxidant activity relationship of ferulates
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154093/
https://www.ncbi.nlm.nih.gov/pubmed/28346342
http://dx.doi.org/10.3390/molecules22040527
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