Effectiveness of Whole, Inactivated, Low Pathogenicity Influenza A(H7N9) Vaccine against Antigenically Distinct, Highly Pathogenic H7N9 Virus

The recent emergence of highly pathogenic influenza A(H7N9) variants poses a great risk to humans. We show that ferrets vaccinated with low pathogenicity H7N9 virus vaccine do not develop severe symptoms after infection with an antigenically distinct, highly pathogenic H7N9 virus. These results demo...

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Detalles Bibliográficos
Autores principales: Hatta, Masato, Zhong, Gongxun, Chiba, Shiho, Lopes, Tiago J.S., Neumann, Gabriele, Kawaoka, Yoshihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2018
Materias:
Dispatch
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154142/
https://www.ncbi.nlm.nih.gov/pubmed/30226171
http://dx.doi.org/10.3201/eid2410.180403
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author Hatta, Masato
Zhong, Gongxun
Chiba, Shiho
Lopes, Tiago J.S.
Neumann, Gabriele
Kawaoka, Yoshihiro
author_facet Hatta, Masato
Zhong, Gongxun
Chiba, Shiho
Lopes, Tiago J.S.
Neumann, Gabriele
Kawaoka, Yoshihiro
author_sort Hatta, Masato
collection PubMed
description The recent emergence of highly pathogenic influenza A(H7N9) variants poses a great risk to humans. We show that ferrets vaccinated with low pathogenicity H7N9 virus vaccine do not develop severe symptoms after infection with an antigenically distinct, highly pathogenic H7N9 virus. These results demonstrate the protective benefits of this H7N9 vaccine.
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spelling pubmed-61541422018-10-01 Effectiveness of Whole, Inactivated, Low Pathogenicity Influenza A(H7N9) Vaccine against Antigenically Distinct, Highly Pathogenic H7N9 Virus Hatta, Masato Zhong, Gongxun Chiba, Shiho Lopes, Tiago J.S. Neumann, Gabriele Kawaoka, Yoshihiro Emerg Infect Dis Dispatch The recent emergence of highly pathogenic influenza A(H7N9) variants poses a great risk to humans. We show that ferrets vaccinated with low pathogenicity H7N9 virus vaccine do not develop severe symptoms after infection with an antigenically distinct, highly pathogenic H7N9 virus. These results demonstrate the protective benefits of this H7N9 vaccine. Centers for Disease Control and Prevention 2018-10 /pmc/articles/PMC6154142/ /pubmed/30226171 http://dx.doi.org/10.3201/eid2410.180403 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Dispatch
Hatta, Masato
Zhong, Gongxun
Chiba, Shiho
Lopes, Tiago J.S.
Neumann, Gabriele
Kawaoka, Yoshihiro
Effectiveness of Whole, Inactivated, Low Pathogenicity Influenza A(H7N9) Vaccine against Antigenically Distinct, Highly Pathogenic H7N9 Virus
title Effectiveness of Whole, Inactivated, Low Pathogenicity Influenza A(H7N9) Vaccine against Antigenically Distinct, Highly Pathogenic H7N9 Virus
title_full Effectiveness of Whole, Inactivated, Low Pathogenicity Influenza A(H7N9) Vaccine against Antigenically Distinct, Highly Pathogenic H7N9 Virus
title_fullStr Effectiveness of Whole, Inactivated, Low Pathogenicity Influenza A(H7N9) Vaccine against Antigenically Distinct, Highly Pathogenic H7N9 Virus
title_full_unstemmed Effectiveness of Whole, Inactivated, Low Pathogenicity Influenza A(H7N9) Vaccine against Antigenically Distinct, Highly Pathogenic H7N9 Virus
title_short Effectiveness of Whole, Inactivated, Low Pathogenicity Influenza A(H7N9) Vaccine against Antigenically Distinct, Highly Pathogenic H7N9 Virus
title_sort effectiveness of whole, inactivated, low pathogenicity influenza a(h7n9) vaccine against antigenically distinct, highly pathogenic h7n9 virus
topic Dispatch
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154142/
https://www.ncbi.nlm.nih.gov/pubmed/30226171
http://dx.doi.org/10.3201/eid2410.180403
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