Rapid Increase in Carriage Rates of Enterobacteriaceae Producing Extended-Spectrum β-Lactamases in Healthy Preschool Children, Sweden

By collecting and analyzing diapers, we identified a >6-fold increase in carriage of extended-spectrum β-lactamase (ESBL)–producing Enterobacteriaceae for healthy preschool children in Sweden (p<0.0001). For 6 of the 50 participating preschools, the carriage rate was >40%. We analyzed sampl...

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Autores principales: Kaarme, Johan, Riedel, Hilde, Schaal, Wesley, Yin, Hong, Nevéus, Tryggve, Melhus, Åsa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154144/
https://www.ncbi.nlm.nih.gov/pubmed/30226162
http://dx.doi.org/10.3201/eid2410.171842
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author Kaarme, Johan
Riedel, Hilde
Schaal, Wesley
Yin, Hong
Nevéus, Tryggve
Melhus, Åsa
author_facet Kaarme, Johan
Riedel, Hilde
Schaal, Wesley
Yin, Hong
Nevéus, Tryggve
Melhus, Åsa
author_sort Kaarme, Johan
collection PubMed
description By collecting and analyzing diapers, we identified a >6-fold increase in carriage of extended-spectrum β-lactamase (ESBL)–producing Enterobacteriaceae for healthy preschool children in Sweden (p<0.0001). For 6 of the 50 participating preschools, the carriage rate was >40%. We analyzed samples from 334 children and found 56 containing >1 ESBL producer. The prevalence in the study population increased from 2.6% in 2010 to 16.8% in 2016 (p<0.0001), and for 6 of the 50 participating preschools, the carriage rate was >40%. Furthermore, 58% of the ESBL producers were multidrug resistant, and transmission of ESBL-producing and non–ESBL-producing strains was observed at several of the preschools. Toddlers appear to be major carriers of ESBL producers in Sweden.
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spelling pubmed-61541442018-10-01 Rapid Increase in Carriage Rates of Enterobacteriaceae Producing Extended-Spectrum β-Lactamases in Healthy Preschool Children, Sweden Kaarme, Johan Riedel, Hilde Schaal, Wesley Yin, Hong Nevéus, Tryggve Melhus, Åsa Emerg Infect Dis Research By collecting and analyzing diapers, we identified a >6-fold increase in carriage of extended-spectrum β-lactamase (ESBL)–producing Enterobacteriaceae for healthy preschool children in Sweden (p<0.0001). For 6 of the 50 participating preschools, the carriage rate was >40%. We analyzed samples from 334 children and found 56 containing >1 ESBL producer. The prevalence in the study population increased from 2.6% in 2010 to 16.8% in 2016 (p<0.0001), and for 6 of the 50 participating preschools, the carriage rate was >40%. Furthermore, 58% of the ESBL producers were multidrug resistant, and transmission of ESBL-producing and non–ESBL-producing strains was observed at several of the preschools. Toddlers appear to be major carriers of ESBL producers in Sweden. Centers for Disease Control and Prevention 2018-10 /pmc/articles/PMC6154144/ /pubmed/30226162 http://dx.doi.org/10.3201/eid2410.171842 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Research
Kaarme, Johan
Riedel, Hilde
Schaal, Wesley
Yin, Hong
Nevéus, Tryggve
Melhus, Åsa
Rapid Increase in Carriage Rates of Enterobacteriaceae Producing Extended-Spectrum β-Lactamases in Healthy Preschool Children, Sweden
title Rapid Increase in Carriage Rates of Enterobacteriaceae Producing Extended-Spectrum β-Lactamases in Healthy Preschool Children, Sweden
title_full Rapid Increase in Carriage Rates of Enterobacteriaceae Producing Extended-Spectrum β-Lactamases in Healthy Preschool Children, Sweden
title_fullStr Rapid Increase in Carriage Rates of Enterobacteriaceae Producing Extended-Spectrum β-Lactamases in Healthy Preschool Children, Sweden
title_full_unstemmed Rapid Increase in Carriage Rates of Enterobacteriaceae Producing Extended-Spectrum β-Lactamases in Healthy Preschool Children, Sweden
title_short Rapid Increase in Carriage Rates of Enterobacteriaceae Producing Extended-Spectrum β-Lactamases in Healthy Preschool Children, Sweden
title_sort rapid increase in carriage rates of enterobacteriaceae producing extended-spectrum β-lactamases in healthy preschool children, sweden
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154144/
https://www.ncbi.nlm.nih.gov/pubmed/30226162
http://dx.doi.org/10.3201/eid2410.171842
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