Visible-Light Photocatalytic Difluoroalkylation-Induced 1, 2-Heteroarene Migration of Allylic Alcohols in Batch and Flow

[Image: see text] A convenient method for the preparation of sp(3)-rich heterocycles is reported. The method comprises a photocatalytic difluoroalkylation-induced 1,2-heteroarene migration of allylic alcohols. Here we describe for the first time the benefits of using flow to facilitate such migratio...

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Detalles Bibliográficos
Autores principales: Wei, Xiao-Jing, Noël, Timothy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2018
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154216/
https://www.ncbi.nlm.nih.gov/pubmed/30020781
http://dx.doi.org/10.1021/acs.joc.8b01624
Descripción
Sumario:[Image: see text] A convenient method for the preparation of sp(3)-rich heterocycles is reported. The method comprises a photocatalytic difluoroalkylation-induced 1,2-heteroarene migration of allylic alcohols. Here we describe for the first time the benefits of using flow to facilitate such migration reactions, including shorter reaction times, higher selectivities, and opportunities to scale the chemistry.

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