Visible-Light Photocatalytic Difluoroalkylation-Induced 1, 2-Heteroarene Migration of Allylic Alcohols in Batch and Flow

[Image: see text] A convenient method for the preparation of sp(3)-rich heterocycles is reported. The method comprises a photocatalytic difluoroalkylation-induced 1,2-heteroarene migration of allylic alcohols. Here we describe for the first time the benefits of using flow to facilitate such migratio...

Descripción completa

Detalles Bibliográficos
Autores principales: Wei, Xiao-Jing, Noël, Timothy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2018
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154216/
https://www.ncbi.nlm.nih.gov/pubmed/30020781
http://dx.doi.org/10.1021/acs.joc.8b01624
_version_ 1783357658514849792
author Wei, Xiao-Jing
Noël, Timothy
author_facet Wei, Xiao-Jing
Noël, Timothy
author_sort Wei, Xiao-Jing
collection PubMed
description [Image: see text] A convenient method for the preparation of sp(3)-rich heterocycles is reported. The method comprises a photocatalytic difluoroalkylation-induced 1,2-heteroarene migration of allylic alcohols. Here we describe for the first time the benefits of using flow to facilitate such migration reactions, including shorter reaction times, higher selectivities, and opportunities to scale the chemistry.
format Online
Article
Text
id pubmed-6154216
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher American Chemical Society
record_format MEDLINE/PubMed
spelling pubmed-61542162018-09-27 Visible-Light Photocatalytic Difluoroalkylation-Induced 1, 2-Heteroarene Migration of Allylic Alcohols in Batch and Flow Wei, Xiao-Jing Noël, Timothy J Org Chem [Image: see text] A convenient method for the preparation of sp(3)-rich heterocycles is reported. The method comprises a photocatalytic difluoroalkylation-induced 1,2-heteroarene migration of allylic alcohols. Here we describe for the first time the benefits of using flow to facilitate such migration reactions, including shorter reaction times, higher selectivities, and opportunities to scale the chemistry. American Chemical Society 2018-07-18 2018-09-21 /pmc/articles/PMC6154216/ /pubmed/30020781 http://dx.doi.org/10.1021/acs.joc.8b01624 Text en Copyright © 2018 American Chemical Society This is an open access article published under a Creative Commons Non-Commercial No Derivative Works (CC-BY-NC-ND) Attribution License (http://pubs.acs.org/page/policy/authorchoice_ccbyncnd_termsofuse.html) , which permits copying and redistribution of the article, and creation of adaptations, all for non-commercial purposes.
spellingShingle Wei, Xiao-Jing
Noël, Timothy
Visible-Light Photocatalytic Difluoroalkylation-Induced 1, 2-Heteroarene Migration of Allylic Alcohols in Batch and Flow
title Visible-Light Photocatalytic Difluoroalkylation-Induced 1, 2-Heteroarene Migration of Allylic Alcohols in Batch and Flow
title_full Visible-Light Photocatalytic Difluoroalkylation-Induced 1, 2-Heteroarene Migration of Allylic Alcohols in Batch and Flow
title_fullStr Visible-Light Photocatalytic Difluoroalkylation-Induced 1, 2-Heteroarene Migration of Allylic Alcohols in Batch and Flow
title_full_unstemmed Visible-Light Photocatalytic Difluoroalkylation-Induced 1, 2-Heteroarene Migration of Allylic Alcohols in Batch and Flow
title_short Visible-Light Photocatalytic Difluoroalkylation-Induced 1, 2-Heteroarene Migration of Allylic Alcohols in Batch and Flow
title_sort visible-light photocatalytic difluoroalkylation-induced 1, 2-heteroarene migration of allylic alcohols in batch and flow
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154216/
https://www.ncbi.nlm.nih.gov/pubmed/30020781
http://dx.doi.org/10.1021/acs.joc.8b01624
work_keys_str_mv AT weixiaojing visiblelightphotocatalyticdifluoroalkylationinduced12heteroarenemigrationofallylicalcoholsinbatchandflow
AT noeltimothy visiblelightphotocatalyticdifluoroalkylationinduced12heteroarenemigrationofallylicalcoholsinbatchandflow

Ejemplares similares