Cargando…

Cerebral Blood Flow and Cognitive Functioning in a Community-Based, Multi-Ethnic Cohort: The SABRE Study

Introduction: Lower cerebral blood flow (CBF) is associated with cardiovascular disease and vascular risk factors, and is increasingly acknowledged as an important contributor to cognitive decline and dementia. In this cross-sectional study, we examined the association between CBF and cognitive func...

Descripción completa

Detalles Bibliográficos
Autores principales: Leeuwis, Anna E., Smith, Lorna A., Melbourne, Andrew, Hughes, Alun D., Richards, Marcus, Prins, Niels D., Sokolska, Magdalena, Atkinson, David, Tillin, Therese, Jäger, Hans R., Chaturvedi, Nish, van der Flier, Wiesje M., Barkhof, Frederik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154257/
https://www.ncbi.nlm.nih.gov/pubmed/30279656
http://dx.doi.org/10.3389/fnagi.2018.00279
_version_ 1783357661129998336
author Leeuwis, Anna E.
Smith, Lorna A.
Melbourne, Andrew
Hughes, Alun D.
Richards, Marcus
Prins, Niels D.
Sokolska, Magdalena
Atkinson, David
Tillin, Therese
Jäger, Hans R.
Chaturvedi, Nish
van der Flier, Wiesje M.
Barkhof, Frederik
author_facet Leeuwis, Anna E.
Smith, Lorna A.
Melbourne, Andrew
Hughes, Alun D.
Richards, Marcus
Prins, Niels D.
Sokolska, Magdalena
Atkinson, David
Tillin, Therese
Jäger, Hans R.
Chaturvedi, Nish
van der Flier, Wiesje M.
Barkhof, Frederik
author_sort Leeuwis, Anna E.
collection PubMed
description Introduction: Lower cerebral blood flow (CBF) is associated with cardiovascular disease and vascular risk factors, and is increasingly acknowledged as an important contributor to cognitive decline and dementia. In this cross-sectional study, we examined the association between CBF and cognitive functioning in a community-based, multi-ethnic cohort. Methods: From the SABRE (Southall and Brent Revisited) study, we included 214 European, 151 South Asian and 87 African Caribbean participants (71 ± 5 years; 39%F). We used 3T pseudo-continuous arterial spin labeling to estimate whole-brain, hematocrit corrected CBF. We measured global cognition and three cognitive domains (memory, executive functioning/attention and language) with a neuropsychological test battery. Associations were investigated using linear regression analyses, adjusted for demographic variables, vascular risk factors and MRI measures. Results: Across groups, we found an association between higher CBF and better performance on executive functioning/attention (standardized ß [stß] = 0.11, p < 0.05). Stratification for ethnicity showed associations between higher CBF and better performance on memory and executive functioning/attention in the white European group (stß = 0.14; p < 0.05 and stß = 0.18; p < 0.01 respectively), associations were weaker in the South Asian and African Caribbean groups. Conclusions: In a multi-ethnic community-based cohort we showed modest associations between CBF and cognitive functioning. In particular, we found an association between higher CBF and better performance on executive functioning/attention and memory in the white European group. The observations are consistent with the proposed role of cerebral hemodynamics in cognitive decline.
format Online
Article
Text
id pubmed-6154257
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-61542572018-10-02 Cerebral Blood Flow and Cognitive Functioning in a Community-Based, Multi-Ethnic Cohort: The SABRE Study Leeuwis, Anna E. Smith, Lorna A. Melbourne, Andrew Hughes, Alun D. Richards, Marcus Prins, Niels D. Sokolska, Magdalena Atkinson, David Tillin, Therese Jäger, Hans R. Chaturvedi, Nish van der Flier, Wiesje M. Barkhof, Frederik Front Aging Neurosci Neuroscience Introduction: Lower cerebral blood flow (CBF) is associated with cardiovascular disease and vascular risk factors, and is increasingly acknowledged as an important contributor to cognitive decline and dementia. In this cross-sectional study, we examined the association between CBF and cognitive functioning in a community-based, multi-ethnic cohort. Methods: From the SABRE (Southall and Brent Revisited) study, we included 214 European, 151 South Asian and 87 African Caribbean participants (71 ± 5 years; 39%F). We used 3T pseudo-continuous arterial spin labeling to estimate whole-brain, hematocrit corrected CBF. We measured global cognition and three cognitive domains (memory, executive functioning/attention and language) with a neuropsychological test battery. Associations were investigated using linear regression analyses, adjusted for demographic variables, vascular risk factors and MRI measures. Results: Across groups, we found an association between higher CBF and better performance on executive functioning/attention (standardized ß [stß] = 0.11, p < 0.05). Stratification for ethnicity showed associations between higher CBF and better performance on memory and executive functioning/attention in the white European group (stß = 0.14; p < 0.05 and stß = 0.18; p < 0.01 respectively), associations were weaker in the South Asian and African Caribbean groups. Conclusions: In a multi-ethnic community-based cohort we showed modest associations between CBF and cognitive functioning. In particular, we found an association between higher CBF and better performance on executive functioning/attention and memory in the white European group. The observations are consistent with the proposed role of cerebral hemodynamics in cognitive decline. Frontiers Media S.A. 2018-09-18 /pmc/articles/PMC6154257/ /pubmed/30279656 http://dx.doi.org/10.3389/fnagi.2018.00279 Text en Copyright © 2018 Leeuwis, Smith, Melbourne, Hughes, Richards, Prins, Sokolska, Atkinson, Tillin, Jäger, Chaturvedi, Flier and Barkhof. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Leeuwis, Anna E.
Smith, Lorna A.
Melbourne, Andrew
Hughes, Alun D.
Richards, Marcus
Prins, Niels D.
Sokolska, Magdalena
Atkinson, David
Tillin, Therese
Jäger, Hans R.
Chaturvedi, Nish
van der Flier, Wiesje M.
Barkhof, Frederik
Cerebral Blood Flow and Cognitive Functioning in a Community-Based, Multi-Ethnic Cohort: The SABRE Study
title Cerebral Blood Flow and Cognitive Functioning in a Community-Based, Multi-Ethnic Cohort: The SABRE Study
title_full Cerebral Blood Flow and Cognitive Functioning in a Community-Based, Multi-Ethnic Cohort: The SABRE Study
title_fullStr Cerebral Blood Flow and Cognitive Functioning in a Community-Based, Multi-Ethnic Cohort: The SABRE Study
title_full_unstemmed Cerebral Blood Flow and Cognitive Functioning in a Community-Based, Multi-Ethnic Cohort: The SABRE Study
title_short Cerebral Blood Flow and Cognitive Functioning in a Community-Based, Multi-Ethnic Cohort: The SABRE Study
title_sort cerebral blood flow and cognitive functioning in a community-based, multi-ethnic cohort: the sabre study
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154257/
https://www.ncbi.nlm.nih.gov/pubmed/30279656
http://dx.doi.org/10.3389/fnagi.2018.00279
work_keys_str_mv AT leeuwisannae cerebralbloodflowandcognitivefunctioninginacommunitybasedmultiethniccohortthesabrestudy
AT smithlornaa cerebralbloodflowandcognitivefunctioninginacommunitybasedmultiethniccohortthesabrestudy
AT melbourneandrew cerebralbloodflowandcognitivefunctioninginacommunitybasedmultiethniccohortthesabrestudy
AT hughesalund cerebralbloodflowandcognitivefunctioninginacommunitybasedmultiethniccohortthesabrestudy
AT richardsmarcus cerebralbloodflowandcognitivefunctioninginacommunitybasedmultiethniccohortthesabrestudy
AT prinsnielsd cerebralbloodflowandcognitivefunctioninginacommunitybasedmultiethniccohortthesabrestudy
AT sokolskamagdalena cerebralbloodflowandcognitivefunctioninginacommunitybasedmultiethniccohortthesabrestudy
AT atkinsondavid cerebralbloodflowandcognitivefunctioninginacommunitybasedmultiethniccohortthesabrestudy
AT tillintherese cerebralbloodflowandcognitivefunctioninginacommunitybasedmultiethniccohortthesabrestudy
AT jagerhansr cerebralbloodflowandcognitivefunctioninginacommunitybasedmultiethniccohortthesabrestudy
AT chaturvedinish cerebralbloodflowandcognitivefunctioninginacommunitybasedmultiethniccohortthesabrestudy
AT vanderflierwiesjem cerebralbloodflowandcognitivefunctioninginacommunitybasedmultiethniccohortthesabrestudy
AT barkhoffrederik cerebralbloodflowandcognitivefunctioninginacommunitybasedmultiethniccohortthesabrestudy