Assessing Scaffold Diversity of Kinase Inhibitors Using Alternative Scaffold Concepts and Estimating the Scaffold Hopping Potential for Different Kinases

Publicly available kinase inhibitors provide a large source of information for structure–activity relationship analysis and kinase drug design. In this study, publicly available inhibitors of the human kinome were collected and analog series formed by kinase inhibitors systematically identified. The...

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Detalles Bibliográficos
Autores principales: Dimova, Dilyana, Bajorath, Jürgen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154288/
https://www.ncbi.nlm.nih.gov/pubmed/28467353
http://dx.doi.org/10.3390/molecules22050730

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154288/
https://www.ncbi.nlm.nih.gov/pubmed/28467353
http://dx.doi.org/10.3390/molecules22050730

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