Alcohols as Substrates and Solvents for the Construction of 3-Alkoxylated-2-Oxindoles by Direct Alkoxylation of 3-Halooxindoles

Described herein is an environmentally benign method for the synthesis of multisubstituted 3-alkoxylated-2-oxindoles 3 via direct alkoxylation of 3-halooxindoles 1. A wide variety of such multisubstituted 3-alkoxylated-2-oxindole scaffolds were smoothly obtained in good yields (up to 94%) by heating...

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Autores principales: Lin, Bing, Chen, Zhi-Yong, Liu, Huan-Huan, Wei, Qi-Di, Feng, Ting-Ting, Zhou, Ying, Wang, Can, Liu, Xiong-Li, Yuan, Wei-Cheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154289/
https://www.ncbi.nlm.nih.gov/pubmed/28505098
http://dx.doi.org/10.3390/molecules22050801
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author Lin, Bing
Chen, Zhi-Yong
Liu, Huan-Huan
Wei, Qi-Di
Feng, Ting-Ting
Zhou, Ying
Wang, Can
Liu, Xiong-Li
Yuan, Wei-Cheng
author_facet Lin, Bing
Chen, Zhi-Yong
Liu, Huan-Huan
Wei, Qi-Di
Feng, Ting-Ting
Zhou, Ying
Wang, Can
Liu, Xiong-Li
Yuan, Wei-Cheng
author_sort Lin, Bing
collection PubMed
description Described herein is an environmentally benign method for the synthesis of multisubstituted 3-alkoxylated-2-oxindoles 3 via direct alkoxylation of 3-halooxindoles 1. A wide variety of such multisubstituted 3-alkoxylated-2-oxindole scaffolds were smoothly obtained in good yields (up to 94%) by heating in an oil bath at 35 °C for 24 h. A particularly valuable feature of this method was the development of environment-friendly chemistry using alcohols 2 as both the substrates and solvents in the presence of a catalytic amount of base.
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spelling pubmed-61542892018-11-13 Alcohols as Substrates and Solvents for the Construction of 3-Alkoxylated-2-Oxindoles by Direct Alkoxylation of 3-Halooxindoles Lin, Bing Chen, Zhi-Yong Liu, Huan-Huan Wei, Qi-Di Feng, Ting-Ting Zhou, Ying Wang, Can Liu, Xiong-Li Yuan, Wei-Cheng Molecules Article Described herein is an environmentally benign method for the synthesis of multisubstituted 3-alkoxylated-2-oxindoles 3 via direct alkoxylation of 3-halooxindoles 1. A wide variety of such multisubstituted 3-alkoxylated-2-oxindole scaffolds were smoothly obtained in good yields (up to 94%) by heating in an oil bath at 35 °C for 24 h. A particularly valuable feature of this method was the development of environment-friendly chemistry using alcohols 2 as both the substrates and solvents in the presence of a catalytic amount of base. MDPI 2017-05-13 /pmc/articles/PMC6154289/ /pubmed/28505098 http://dx.doi.org/10.3390/molecules22050801 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lin, Bing
Chen, Zhi-Yong
Liu, Huan-Huan
Wei, Qi-Di
Feng, Ting-Ting
Zhou, Ying
Wang, Can
Liu, Xiong-Li
Yuan, Wei-Cheng
Alcohols as Substrates and Solvents for the Construction of 3-Alkoxylated-2-Oxindoles by Direct Alkoxylation of 3-Halooxindoles
title Alcohols as Substrates and Solvents for the Construction of 3-Alkoxylated-2-Oxindoles by Direct Alkoxylation of 3-Halooxindoles
title_full Alcohols as Substrates and Solvents for the Construction of 3-Alkoxylated-2-Oxindoles by Direct Alkoxylation of 3-Halooxindoles
title_fullStr Alcohols as Substrates and Solvents for the Construction of 3-Alkoxylated-2-Oxindoles by Direct Alkoxylation of 3-Halooxindoles
title_full_unstemmed Alcohols as Substrates and Solvents for the Construction of 3-Alkoxylated-2-Oxindoles by Direct Alkoxylation of 3-Halooxindoles
title_short Alcohols as Substrates and Solvents for the Construction of 3-Alkoxylated-2-Oxindoles by Direct Alkoxylation of 3-Halooxindoles
title_sort alcohols as substrates and solvents for the construction of 3-alkoxylated-2-oxindoles by direct alkoxylation of 3-halooxindoles
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154289/
https://www.ncbi.nlm.nih.gov/pubmed/28505098
http://dx.doi.org/10.3390/molecules22050801
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