Isolaurenidificin and Bromlaurenidificin, Two New C(15)-Acetogenins from the Red Alga Laurencia obtusa

Chromatographic fractionation of the CH(2)Cl(2)/MeOH extract of the Red Sea red alga Laurencia obtusa gave two new hexahydrofuro[3,2-b]furan-based C(15)-acetogenins, namely, isolaurenidificin (1) and bromlaurenidificin (2). The chemical structures were elucidated based on extensive analyses of their...

Descripción completa

Detalles Bibliográficos
Autores principales: Bawakid, Nahed O., Alarif, Walied M., Alburae, Najla A., Alorfi, Hajer S., Al-Footy, Khalid O., Al-Lihaibi, Sultan S., Ghandourah, Mohamed A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154321/
https://www.ncbi.nlm.nih.gov/pubmed/28505125
http://dx.doi.org/10.3390/molecules22050807
Descripción
Sumario:Chromatographic fractionation of the CH(2)Cl(2)/MeOH extract of the Red Sea red alga Laurencia obtusa gave two new hexahydrofuro[3,2-b]furan-based C(15)-acetogenins, namely, isolaurenidificin (1) and bromlaurenidificin (2). The chemical structures were elucidated based on extensive analyses of their spectral data. Compounds 1 and 2 showed no toxicity (LC(50) > 12 mM) using Artemia salina as test organism. Both compounds showed weak cytotoxicity against A549, HepG-2, HCT116, MCF-7, and PC-3 cells, however, they exhibited a relatively potent cytotoxic activity against peripheral blood neutrophils. This can be attributed partly to induction of apoptosis.

Ejemplares similares