Cargando…

A 4-Phenoxyphenol Derivative Exerts Inhibitory Effects on Human Hepatocellular Carcinoma Cells through Regulating Autophagy and Apoptosis Accompanied by Downregulating α-Tubulin Expression

Hepatocellular carcinoma (HCC) is a leading cancer worldwide. Advanced HCCs are usually resistant to anticancer drugs, causing unsatisfactory chemotherapy outcomes. In this study, we showed that a 4-phenoxyphenol derivative, 4-[4-(4-hydroxyphenoxy)phenoxy]phenol (4-HPPP), exerts an inhibitory activi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chang, Wen-Tsan, Liu, Wangta, Chiu, Yi-Han, Chen, Bing-Hung, Chuang, Shih-Chang, Chen, Yen-Chun, Hsu, Yun-Tzh, Lu, Mei-Jei, Chiou, Shean-Jaw, Chou, Chon-Kit, Chiu, Chien-Chih
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154338/ https://www.ncbi.nlm.nih.gov/pubmed/28531143 http://dx.doi.org/10.3390/molecules22050854

Ejemplares similares

The Phenoxyphenol Compound 4-HPPP Selectively Induces Antiproliferation Effects and Apoptosis in Human Lung Cancer Cells through Aneupolyploidization and ATR DNA Repair Signaling
por: Liu, Wangta, et al.
Publicado: (2020)

diTFPP, a Phenoxyphenol, Sensitizes Hepatocellular Carcinoma Cells to C(2)-Ceramide-Induced Autophagic Stress by Increasing Oxidative Stress and ER Stress Accompanied by LAMP2 Hypoglycosylation
por: Chiu, Chien-Chih, et al.
Publicado: (2022)

Ethyl Acetate Extract of Scindapsus cf. hederaceus Exerts the Inhibitory Bioactivity on Human Non-Small Cell Lung Cancer Cells through Modulating ER Stress
por: Chou, Chon-Kit, et al.
Publicado: (2018)

The Phenoxyphenol Compound diTFPP Mediates Exogenous C(2)-Ceramide Metabolism, Inducing Cell Apoptosis Accompanied by ROS Formation and Autophagy in Hepatocellular Carcinoma Cells
por: Chang, Wen-Tsan, et al.
Publicado: (2021)

In vivo estrogenicity of p-phenoxyphenol and p-pentyloxyphenol
por: Wang, Yue, et al.
Publicado: (2020)

Negative ion mass spectra of some polychlorinated 2-phenoxyphenols.
por: Busch, K L, et al.
Publicado: (1980)

Analysis of the anticancer activity of curcuminoids, thiotryptophan and 4-phenoxyphenol derivatives
por: PARSAI, SHIREEN, et al.
Publicado: (2014)

Combination Therapy of Chloroquine and C(2)-Ceramide Enhances Cytotoxicity in Lung Cancer H460 and H1299 Cells
por: Chou, Han-Lin, et al.
Publicado: (2019)

Decipher β2-microglobulin: Gain- or loss-of-function (a mini-review)
por: Chiou, Shean-Jaw, et al.
Publicado: (2013)

Natural brominated phenoxyphenols kill persistent and biofilm-incorporated cells of MRSA and other pathogenic bacteria
por: van Geelen, Lasse, et al.
Publicado: (2020)

Correction to: Natural brominated phenoxyphenols kill persistent and biofilm-incorporated cells of MRSA and other pathogenic bacteria
por: van Geelen, Lasse, et al.
Publicado: (2021)

Protective Effects of Lycium barbarum Extracts on UVB-Induced Damage in Human Retinal Pigment Epithelial Cells Accompanied by Attenuating ROS and DNA Damage
por: Hsieh, Feng-Chi, et al.
Publicado: (2018)

A molecular dynamics simulation study decodes the Zika virus NS5 methyltransferase bound to SAH and RNA analogue
por: Chuang, Chih-Hung, et al.
Publicado: (2018)

The Phosphorylation Status of Drp1-Ser637 by PKA in Mitochondrial Fission Modulates Mitophagy via PINK1/Parkin to Exert Multipolar Spindles Assembly during Mitosis
por: Ko, Huey-Jiun, et al.
Publicado: (2021)

Ectromelia virus induces tubulin cytoskeletal rearrangement in immune cells accompanied by a loss of the microtubule organizing center and increased α-tubulin acetylation
por: Szulc-Dąbrowska, Lidia, et al.
Publicado: (2018)

Binding Thermodynamics and Dissociation Kinetics Analysis Uncover the Key Structural Motifs of Phenoxyphenol Derivatives as the Direct InhA Inhibitors and the Hotspot Residues of InhA
por: Zhang, Qianqian, et al.
Publicado: (2022)

A novel role for β2-microglobulin: a precursor of antibacterial chemokine in respiratory epithelial cells
por: Chiou, Shean-Jaw, et al.
Publicado: (2016)

Inhibitory effect of trans-ferulic acid on proliferation and migration of human lung cancer cells accompanied with increased endogenous reactive oxygen species and β-catenin instability
por: Fong, Yao, et al.
Publicado: (2016)

γ-Tubulin 2 Nucleates Microtubules and Is Downregulated in Mouse Early Embryogenesis
por: Vinopal, Stanislav, et al.
Publicado: (2012)

Ftr82 Is Critical for Vascular Patterning during Zebrafish Development
por: Chang, Hsueh-Wei, et al.
Publicado: (2017)

The Double-Edged Sword of Beta2-Microglobulin in Antibacterial Properties and Amyloid Fibril-Mediated Cytotoxicity
por: Chiou, Shean-Jaw, et al.
Publicado: (2021)

Slug increases sensitivity to tubulin-binding agents via the downregulation of βIII and βIVa-tubulin in lung cancer cells
por: Tamura, Daisuke, et al.
Publicado: (2013)

CS-PEI/Beclin-siRNA Downregulate Multidrug Resistance Proteins and Increase Paclitaxel Therapeutic Efficacy against NSCLC
por: Liu, Wangta, et al.
Publicado: (2019)

Coronary Slow Flow Accompanying Exertional Blurred Vision and Effects of Corticosteroids
por: Koç, Şahbender, et al.
Publicado: (2015)

A novel quinoline derivative, DFIQ, sensitizes NSCLC cells to ferroptosis by promoting oxidative stress accompanied by autophagic dysfunction and mitochondrial damage
por: Bow, Yung-Ding, et al.
Publicado: (2023)

Correction: γ-Tubulin 2 Nucleates Microtubules and Is Downregulated in Mouse Early Embryogenesis
por: Vinopal, Stanislav, et al.
Publicado: (2012)

Primary inguinal subcutaneous endometriosis accompanied with an inguinal hernia: A case report
por: Chen, Pei-Chen, et al.
Publicado: (2021)

Intravenous Arginine Administration Downregulates NLRP3 Inflammasome Activity and Attenuates Acute Kidney Injury in Mice with Polymicrobial Sepsis
por: Tanuseputero, Sharon Angela, et al.
Publicado: (2020)

Chemical composition and tyrosinase inhibitory activity of Cinnamomum cassia essential oil
por: Chang, Chen-Tien, et al.
Publicado: (2013)

A polymer-dependent increase in phosphorylation of beta-tubulin accompanies differentiation of a mouse neuroblastoma cell line
Publicado: (1985)

NBM-BMX, an HDAC8 Inhibitor, Overcomes Temozolomide Resistance in Glioblastoma Multiforme by Downregulating the β-Catenin/c-Myc/SOX2 Pathway and Upregulating p53-Mediated MGMT Inhibition
por: Tsai, Cheng-Yu, et al.
Publicado: (2021)

Novel dermacozine-1-carboxamides as promising anticancer agents with tubulin polymerization inhibitory activity
por: Ghanta, Venkata Rao, et al.
Publicado: (2019)

The Downregulation of ADAM17 Exerts Protective Effects against Cardiac Fibrosis by Regulating Endoplasmic Reticulum Stress and Mitophagy
por: Guan, Chang, et al.
Publicado: (2021)

Inhibitory Effects of Resveratrol on the Epstein-Barr Virus Lytic Cycle
por: Yiu, Ching-Yi, et al.
Publicado: (2010)

Prednisolone exerts exquisite inhibitory properties on platelet functions
por: Liverani, Elisabetta, et al.
Publicado: (2012)

Unfolded Protein Response (UPR) in Survival, Dormancy, Immunosuppression, Metastasis, and Treatments of Cancer Cells
por: Hsu, Sheng-Kai, et al.
Publicado: (2019)

Cevipabulin-tubulin complex reveals a novel agent binding site on α-tubulin with tubulin degradation effect
por: Yang, Jianhong, et al.
Publicado: (2021)

BPR1J-097, a novel FLT3 kinase inhibitor, exerts potent inhibitory activity against AML
por: Lin, W-H, et al.
Publicado: (2012)

Cardiac Glycoside Ouabain Exerts Anticancer Activity via Downregulation of STAT3
por: Du, Jie, et al.
Publicado: (2021)

Lactotransferrin Downregulation Drives the Metastatic Progression in Clear Cell Renal Cell Carcinoma
por: Chiu, I-Jen, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_b6q7kk32erh7p08kqlbfevt80c