Molecular dynamics and structure function analysis show that substrate binding and specificity are major forces in the functional diversification of Eqolisins

BACKGROUND: Eqolisins are rare acid proteases found in archaea, bacteria and fungi. Certain fungi secrete acids as part of their lifestyle and interestingly these also have many eqolisin paralogs, up to nine paralogs have been recorded. This suggests a process of functional redundancy and diversific...

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Detalles Bibliográficos
Autores principales: Stocchi, Nicolás, Revuelta, María Victoria, Castronuovo, Priscila Ailín Lanza, Vera, D. Mariano A., ten Have, Arjen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154417/
https://www.ncbi.nlm.nih.gov/pubmed/30249179
http://dx.doi.org/10.1186/s12859-018-2348-2

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