Utilization of voriconazole drug monitoring in the treatment of cutaneous Scedosporium apiospermum infection

We report the use of voriconazole troughs to achieve appropriate therapeutic levels in treatment of a cutaneous Scedosporium apiospermum infection. Following heart transplantation, a 63-year-old immunocompromised patient presented with post-traumatic nodular lesions on his right shin. Pathology show...

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Detalles Bibliográficos
Autores principales: Boyd, McKenna E., Dao, Harry, Estep, Jerry D., Huttenbach, Yve T., Hemmige, Vagish
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154461/
https://www.ncbi.nlm.nih.gov/pubmed/30258765
http://dx.doi.org/10.1016/j.mmcr.2018.09.002
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author Boyd, McKenna E.
Dao, Harry
Estep, Jerry D.
Huttenbach, Yve T.
Hemmige, Vagish
author_facet Boyd, McKenna E.
Dao, Harry
Estep, Jerry D.
Huttenbach, Yve T.
Hemmige, Vagish
author_sort Boyd, McKenna E.
collection PubMed
description We report the use of voriconazole troughs to achieve appropriate therapeutic levels in treatment of a cutaneous Scedosporium apiospermum infection. Following heart transplantation, a 63-year-old immunocompromised patient presented with post-traumatic nodular lesions on his right shin. Pathology showed fungal yeasts with culture revealing Scedosporium apiospermum. According to therapeutic drug monitoring, initial voriconazole treatment was subtherapeutic requiring increased dosing until appropriate therapeutic trough levels were attained, and resolution of the fungal infection was achieved.
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spelling pubmed-61544612018-09-26 Utilization of voriconazole drug monitoring in the treatment of cutaneous Scedosporium apiospermum infection Boyd, McKenna E. Dao, Harry Estep, Jerry D. Huttenbach, Yve T. Hemmige, Vagish Med Mycol Case Rep Case Report We report the use of voriconazole troughs to achieve appropriate therapeutic levels in treatment of a cutaneous Scedosporium apiospermum infection. Following heart transplantation, a 63-year-old immunocompromised patient presented with post-traumatic nodular lesions on his right shin. Pathology showed fungal yeasts with culture revealing Scedosporium apiospermum. According to therapeutic drug monitoring, initial voriconazole treatment was subtherapeutic requiring increased dosing until appropriate therapeutic trough levels were attained, and resolution of the fungal infection was achieved. Elsevier 2018-09-13 /pmc/articles/PMC6154461/ /pubmed/30258765 http://dx.doi.org/10.1016/j.mmcr.2018.09.002 Text en © 2018 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Boyd, McKenna E.
Dao, Harry
Estep, Jerry D.
Huttenbach, Yve T.
Hemmige, Vagish
Utilization of voriconazole drug monitoring in the treatment of cutaneous Scedosporium apiospermum infection
title Utilization of voriconazole drug monitoring in the treatment of cutaneous Scedosporium apiospermum infection
title_full Utilization of voriconazole drug monitoring in the treatment of cutaneous Scedosporium apiospermum infection
title_fullStr Utilization of voriconazole drug monitoring in the treatment of cutaneous Scedosporium apiospermum infection
title_full_unstemmed Utilization of voriconazole drug monitoring in the treatment of cutaneous Scedosporium apiospermum infection
title_short Utilization of voriconazole drug monitoring in the treatment of cutaneous Scedosporium apiospermum infection
title_sort utilization of voriconazole drug monitoring in the treatment of cutaneous scedosporium apiospermum infection
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154461/
https://www.ncbi.nlm.nih.gov/pubmed/30258765
http://dx.doi.org/10.1016/j.mmcr.2018.09.002
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