Distal Proton Shuttle Mechanism of Ribosome Catalysed Peptide Bond Formation—A Theoretical Study

In this work, we have investigated a novel distal proton shuttle mechanism of ribosome catalyzed peptide bond formation reaction. The reaction was found to follow a two-step mechanism. A distal water molecule located about 6.1 Å away from the attacking amine plays as a proton acceptor and results in...

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Detalles Bibliográficos
Autores principales: Zhang, Xiaotong, Jiang, Yafei, Mao, Qiuyun, Tan, Hongwei, Li, Xichen, Chen, Guangju, Jia, Zongchao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154465/
https://www.ncbi.nlm.nih.gov/pubmed/28362358
http://dx.doi.org/10.3390/molecules22040571

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154465/
https://www.ncbi.nlm.nih.gov/pubmed/28362358
http://dx.doi.org/10.3390/molecules22040571

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